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Inhibitor of prostaglandin and leukotriene synthesis
ALX-270-360-M005 5 mg 294.00 USD
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Potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Selective inhibitor of cyclooxygenase 2 (COX-2). Inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Inhibits the production of IFN-γ and IL-2 after stimulation of Peyer's patch lymphocytes with staphylococcal enterotoxin B (SEB). Inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin (Prod. No. BML-GR319) resistance on breast cancer cells.

Product Details

Purity:≥98% (1H-NMR, HPLC)
Identity:Determined by 1H-NMR, 13C-NMR, IR, MS and UV.
Appearance:Yellow needles.
Solubility:Soluble in DMSO (8mg/ml) or methanol (0.3mg/ml); sparingly soluble in water (2.5µg/ml).
Shipping:Ambient Temperature
Long Term Storage:+4°C
Use/Stability:Stable for at least 2 years after receipt when stored at +4°C in the dark. Stock solutions made in DMSO must be stored in the dark no longer than one month.
Handling:Protect from light and moisture.
Scientific Background:Tryptanthrin occurs as a natural product in various plants: Isatis tinctoria, I. indigotica, Polygonum tinctorium, Couroupita guianensis, Wrightia tinctoria, Calanthe discolor, Phaius mishmensis, Strobilanthes cusia.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells: K. Iwaki, et al.; J. Ethnopharmacol. 134, 450 (2011), Abstract;
Modulatory effects and action mechanisms of tryptanthrin on murine myeloid leukemia cells: H.L. Chan, et al.; Cell Mol. Immunol. 6, 335 (2009), Abstract; Full Text
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells: S.T. Yu, et al.; BBRC 358, 79 (2007), Abstract;
Tryptanthrin inhibits interferon-gamma production by Peyer’s patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin: Y. Takei, et al.; Biol. Pharm. Bull. 26, 365 (2003), Abstract;
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis: H. Danz, et al.; Planta Med. 68, 875 (2002), Abstract;
Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001), Abstract;
H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000),
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages: T. Ishihara, et al.; Eur. J. Pharmacol. 407, 197 (2000), Abstract;
Tuberculosis: a search for novel therapy starting with natural products: L.A. Mitschler & W. Baker; Med. Res. Rev. 18, 363 (1998), Abstract;

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