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Caffeic acid

Lipoxygenase inhibitor
ALX-270-231-G001 1 g 31.00 USD
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Replaces Prod. #: BML-EI124

Naturally occuring phenolic compound found in many fruits, vegetables and herbs, including coffee. Shows anti-tumor, antiviral, antioxidant and anti-inflammatory effects. Inhibitor of 5- and 12-lipoxygenase (LO) (5-LO, IC50=3.7µM).

Product Details

Alternative Name:3-(3,4-Dihydroxyphenyl)-2-propenoic acid, 3,4-Dihydroxycinnamic acid
MI:14: 1635
Purity:≥97% (HPLC)
Identity:Determined by IR.
Appearance:Off-white to brown crystalline solid.
Solubility:Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS, pH 7.2.
Long Term Storage:Ambient
Use/Stability:Stable for at least 2 years when stored at +20°C. Organic stock solutions are stable for at least 6 months when stored at –20°C. Store aqueous solutions of the product on ice and use within 12 hours of preparation.
Handling:Protect from oxygen.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Anti-HIV activities of natural antioxidant caffeic acid derivatives: toward an antiviral supplementation diet: F. Bailly & P. Cotelle; Curr. Med. Chem. 12, 1811 (2005), Abstract;
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties: F.M. da Cunha, et al.; Free Radic. Res. 38, 1241 (2004), Abstract;
Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism: T.W. Chung, et al.; FASEB J. 18, 1670 (2004), Abstract;
Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives: N. Kohyama, et al.; Biosci. Biotech. Biochem. 61, 347 (1997), Abstract;
Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon: C.V. Rao, et al.; Cancer Res. 53, 4182 (1993), Abstract;
Caffeic acid is a selective inhibitor for leukotriene biosynthesis: Y. Koshihara, et al.; Biochim. Biophys. Acta 792, 92 (1984), Abstract;

General Literature References

15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells: I. Shureiqi, et al.; Cancer Res. 60, 6846 (2000), Abstract;
15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells: I. Shureiqi, et al.; J. Natl. Cancer Inst. 92, 1136 (2000), Abstract;
Xanthine oxidase inhibitors from the leaves of Alsophila spinulosa (Hook) Tryon: H.C. Chiang, et al.; J. Enzyme Inhib. 8, 61 (1994), Abstract;

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