Replaces Prod. #: BML-FR102
Active component of propolis from honeybee hives, known to have anti-mitogenic, anti-carcinogenic, anti-inflammatory, and immunomodulatory properties. Potent and specific inhibitor of NF-κB activation, induced by TNF-α (Prod. No. ALX-522-008 (human) or Prod. No. ALX-522-009 (mouse)), PMA (Prod. No. BML-PE160) and other inflammatory agents. Exhibits inhibitory activity against HIV-1 integrase (IC50=7µM). Suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. Induces apoptosis.
Product Details
Alternative Name: | CAPE, Phenethyl caffeiate, Caffeic acid phenethyl ester |
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Formula: | C17H16O4 |
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MW: | 284.3 |
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Source: | Synthetic. |
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CAS: | 104594-70-9 |
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Purity: | ≥97% (HPLC) |
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Appearance: | White to off-white crystalline solid. |
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Solubility: | 10mg/ml soluble in DMSO, 100% ethanol, methanol, acetone or acetonitrile; insoluble in water. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least one year after receipt when stored at -20°C. |
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Handling: | Protect from light and moisture. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Choline Chloride-urea Deep Eutectic Mixture Water for the Synthesis of an Amphiphilic Compound of Glyceryl Monocaffeate: F.N. Gonawan, et al.; J. Oleo Sci.
5650, 21010 (2021),
Abstract;
Curcumin suppresses NTHi-induced CXCL5 expression via inhibition of positive IKKβ pathway and up-regulation of negative MKP-1 pathway: A.S. Konduru, et al.; Sci. Rep.
6, 31695 (2016),
Application(s): Cell culture, effect on nuclear translocation of p65,
Abstract;
Full Text
Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR: K. Suzuki, et al.; Biofactors
28, 151 (2006),
Abstract;
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties: F.M. da Cunha, et al.; Free Radic. Res.
38, 1241 (2004),
Abstract;
Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors: N. Marquez, et al.; J. Pharmacol. Exp. Ther.
308, 993 (2004),
Abstract;
Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation: Z. Orban, et al.; Neuroimmunomodulation
7, 99 (2000),
Abstract;
Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation: P. Michaluart, et al.; Cancer Res.
59, 2347 (1999),
Abstract;
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B: K. Natarajan, et al.; PNAS
93, 9090 (1996),
Abstract;
Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells: C. Chiao, et al.; Cancer Res.
55, 3576 (1995),
Abstract;
Hydroxylated aromatic inhibitors of HIV-1 integrase: T.R. Burke Jr., et al.; J. Med. Chem.
38, 4171 (1995),
Abstract;
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