Replaces Prod. #: ALX-804-066
Product Details
| Alternative Name: | Postsynaptic density protein 95, Disks large homolog 4, Synapse-associated protein 90, SAP90 |
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| Clone: | 7E3-1B8 |
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| Host: | Mouse |
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| Isotype: | IgG2a |
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| Immunogen: | Recombinant rat PSD-95. |
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| UniProt ID: | Q62108 |
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| Source: | Purified from ascites. |
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| Species reactivity: | Mouse, Rat
Bovine
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~95kDa by Western blot. |
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Postsynaptic density protein 95 kDa (PSD-95), also known as Synapse associated protein 90 kDa (SAP90), is a brain specific protein that is highly similar to the Drosophila dlg tumor suppressor protein. PSD-95 is a member of membrane associated proteins that are localized beneath the postsynaptic membrane of synapses in the CNS. PSD-95 interacts with NMDA receptor and Shaker-type K+ channels and contributes to their clustering and localization at the synaptic spines in hippocampal neurons and the pinceau terminal of cerebellar basket cells, respectively. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of bovine brain tissue extract, probed with PSD-95, mAb (7E3-1B8).
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Product Literature References
Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons: D. Toyoshima, et al.; PLoS One
9, e89763 (2014),
Application(s): Western blot,
Abstract;
Full Text
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