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PSD-95 monoclonal antibody (7E3-1B8)

ADI-VAM-PS001-E 100 µg 363.00 USD
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Replaces Prod. #: ALX-804-066

Product Details

Alternative Name:Postsynaptic density protein 95, Disks large homolog 4, Synapse-associated protein 90, SAP90
Immunogen:Recombinant rat PSD-95.
UniProt ID:Q62108
Source:Purified from ascites.
Species reactivity:Mouse, Rat
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~95kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Postsynaptic density protein 95 kDa (PSD-95), also known as Synapse associated protein 90 kDa (SAP90), is a brain specific protein that is highly similar to the Drosophila dlg tumor suppressor protein. PSD-95 is a member of membrane associated proteins that are localized beneath the postsynaptic membrane of synapses in the CNS. PSD-95 interacts with NMDA receptor and Shaker-type K+ channels and contributes to their clustering and localization at the synaptic spines in hippocampal neurons and the pinceau terminal of cerebellar basket cells, respectively.
Regulatory Status:RUO - Research Use Only
PSD-95 monoclonal antibody (7E3-1B8) Western blot
Western blot analysis of bovine brain tissue extract, probed with PSD-95, mAb (7E3-1B8).
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PSD-95 monoclonal antibody (7E3-1B8) Western blot

Product Literature References

Fmr1-KO mice failure to detect object novelty associates with a post-test decrease of structural and synaptic plasticity upstream of the hippocampus: A. Borreca, et al.; Sci. Rep. 13, 755 (2023), Abstract;
Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons: D. Toyoshima, et al.; PLoS One 9, e89763 (2014), Application(s): Western blot, Abstract; Full Text

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