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HSP90 polyclonal antibody

ADI-SPA-846-D 50 µg 192.00 USD
ADI-SPA-846-F 200 µg 457.00 USD
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Product Details

Alternative Name:HSP86, Heat shock protein 90β
Immunogen:Human Hsp90.
UniProt ID:P07900 (HSP90alpha), P08238 (HSP90beta)
Source:Purified from rabbit serum.
Species reactivity:Human, Mouse, Rat
Applications:IHC (PS), WB
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~90kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
Regulatory Status:RUO - Research Use Only
HSP90 polyclonal antibody Western blot
Western blot analysis of HSP90: Lane 1: MW marker, Lane 2: HSP90 Native Human Protein, Lane 3: HSP90α Recombinant Human Protein, Lane 4: HeLa, Lane 5: 3T3, Lane 6: PC-12, Lane 7: RK-13.
HSP90 polyclonal antibody Immunohistochemistry
Immunohistochemistry analysis of human spleen tissue stained with HSP90, pAb at 10µg/ml.
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HSP90 polyclonal antibody Western blot HSP90 polyclonal antibody Immunohistochemistry

Product Literature References

Exendin-4, a glucagon-like peptide receptor agonist, facilitates osteoblast differentiation via connexin43: J. Chen, et al.; Endocrine 72, 672 (2021), Abstract;
Nuclear export factor 3 regulates localization of small nucleolar RNAs: M.W. Li, et al.; J. Biol. Chem. 292, 20228 (2017), Abstract; Full Text
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP: S. Sun, et al.; Nat. Commun. 6, 6171 (2015), Application(s): Western Blotting, Abstract;
Cytosolic Accumulation of Small Nucleolar RNAs (snoRNAs) is Dynamically Regulated by NADPH Oxidase: C.L. Holley, et al.; J. Biol. Chem. 290, 11741 (2015), Application(s): Western Blotting, Abstract; Full Text
Basal and stress-induced Hsp70 are modulated by ataxin-3: C.P. Reina, et al.; Cell Stress Chaperones 17, 729 (2012), Application(s): WB using mouse cell lysate, Abstract; Full Text
Stress-induced activation of ovarian heat shock protein 90 in a rat model of polycystic ovary syndrome: E. Park, et al.; J. Obstet. Gynaecol. Res. 38, 396 (2012), Application(s): Western Blot and IHC on FFPE of rat ovary, Abstract;

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