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PDK1 polyclonal antibody

ADI-KAP-PK112-D 50 µg 199.00 USD
ADI-KAP-PK112-F 200 µg 457.00 USD
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Product Details

Alternative Name:Pyruvate dehydrogenase kinase
Immunogen:Synthetic peptide corresponding to a portion of human PDK1 (Pyruvate dehydrogenase kinase-1).
UniProt ID:Q15118
GenBank ID:L42450
Source:Purified from rabbit serum.
Species reactivity:Human, Mouse, Rat
Dog, Monkey, Porcine, Rabbit
Applications:IHC (PS), WB
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~48kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:PDK-1 (Pyruvate dehydrogenase kinase-1) is a 48 kDa protein kinase. It is a member of the mitrochondrial matrix protein kinase family and is related to the histidine protein kinases found in prokaryotes. PDK-1 is responsible for phosphorylation and concomitant inactivation of pyruvate dehydrogenase.
Regulatory Status:RUO - Research Use Only
PDK1 polyclonal antibody Immunohistochemistry
Immunohistochemistry analysis of human spleen tissue stained with PDK1, pAb at 10µg/ml.
PDK1 polyclonal antibody Western blot
Western blot analysis of PDK1, pAb (Prod. No. KAP-PK112): Lane 1: MW Marker, Lane 2: HeLa Cell Lysate (Prod. No. ADI-LYC-HL100), Lane 3: Rat Brain Lysate (Prod. No. ADI-LYT-RB100), Lane 4: Mouse Brain Lysate (Prod. No. ADI-LYT-MB100), Lane 5: ESK-4 cell Lysate, Lane 6: RK-13 Cell Lysate, Lane 7: MCDK Cell Lysate, Lane 8: Vero Lysate
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PDK1 polyclonal antibody Immunohistochemistry PDK1 polyclonal antibody Western blot

Product Literature References

Andrographolide suppresses aerobic glycolysis and induces apoptotic cell death by inhibiting pyruvate dehydrogenase kinase 1 expression: E.S. Yang, et al.; Oncol. Rep. 49, 72 (2023), Abstract;
Inhibition of pyruvate dehydrogenase kinase 4 in CD4+ T cells ameliorates intestinal inflammation: H. Lee, et al.; Cell. Mol. Gastroenterol. Hepatol. 15, 439 (2023), Abstract;
Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma: H. Lu, et al.; JCI Insight 4, e131106 (2019), Abstract; Full Text
ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis: H. Lu, et al.; Cancer Lett. 381, 23 (2016), Application(s): Western blotting and Immunoprecipitation, Abstract;
Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours: T. Golias, et al.; Sci. Rep. 6, 31146 (2016), Application(s): Western blotting antibodies, Abstract; Full Text
Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis: G.N. Valbuena, et al.; Mol. Neurobiol. 53, 2222 (2016), Application(s): Western Blot, Abstract; Full Text
Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism: Z. Ai, et al.; Cancer Lett. 373, 36 (2016), Application(s): Western blot, Abstract; Full Text
Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor kaiso: C.C. Pierre, et al.; Biochim. Biophys. Acta 1849, 1432 (2015), Application(s): Immunoblot analysis, Abstract;
pVHL is a regulator of glucose metabolism and insulin secretion in pancreatic β cells: W. Krek, et al. ; Genes Dev. 22, 3135 (2008), Application(s): WB using mouse cell lysates, Abstract;
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels: S.L. Archer, et al. ; Circulation 105, 244 (2002), Application(s): WB using rat samples, Abstract;

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