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Vasopressin receptor V1a polyclonal antibody

ADI-905-811-100 100 µg 415.00 USD
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Product Details

Alternative Name:AVPR1A
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of rat vasopressin receptor V1a.
UniProt ID:P30560
Species reactivity:Human, Mouse, Rat
Crossreactivity:Predicted species reactivity based on epitope sequence homology: rhesus macaque, dog, bovine.
Application Notes:Predicted MW of ~48kDa. Higher MW species (~50kDa) also observed by Western blot which reflects post-translational modification of the receptor.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
Handling:Keep on ice at all times.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven-transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1) receptors regulate vasoconstriction, and are expressed in vascular smooth muscle, kidney, myometrium, bladder, adipocytes, hepatocytes, platelets and testis; V1b (V3) receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus; and V2 receptors of the kidney regulate the antidiuretic effects of AVP. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas.
Regulatory Status:RUO - Research Use Only
Manufacturer:Manufactured by Proteimax.
Vasopressin receptor V1a polyclonal antibody Western blot
Western blot analysis: MW Marker (1) and 20µg of rat kidney extract (2), probed with Vasopressin Receptor (V1a) pAb at 1µg/ml.
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Vasopressin receptor V1a polyclonal antibody Western blot

Product Literature References

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states: A.S. Heimann, et al.; PloS One 12, e0187306 (2017), Abstract; Full Text

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