1,000-fold more potent inhibitor of CDK1/cyclin B (IC50=9.5nM) and CDK2/cyclin A3 (IC50=5.4nM) than NU2058 (Prod. No. ALX-270-394). Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50=1.6µM), DYRK1A (IC50=0.9µM), PDK1 (IC50=0.8µM) and ROCKII (IC50=0.6µM).
Product Details
| Formula: | C18H22N6O3S |
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| MW: | 402.5 |
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| CAS: | 444722-95-6 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Packaged under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2: I.R. Hardcastle, et al.; J. Med. Chem.
47, 3710 (2004),
Abstract;
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2: K.L. Sayle, et al.; Bioorg. Med. Chem. Lett.
13, 3079 (2003),
Abstract;
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor: T.G. Davies, et al.; Nat. Struct. Biol.
9, 745 (2002),
Abstract;
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