Competitive inhibitor of CDK1/cyclin B (IC50=5µM) and CDK2/cyclin A (IC50=12µM). Pharmacologically distinct from the relative specific inhibitor of CDK1/2 roscovitine (Prod. No. BML-CC205).
Product Details
| Alternative Name: | O6-Cyclohexylmethylguanine |
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| Formula: | C12H17N5O |
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| MW: | 247.3 |
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| CAS: | 161058-83-9 |
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| Solubility: | Soluble in water or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2: L.R. Harrison, et al.; Biochem. Pharmacol.
77, 1586 (2009),
Abstract;
The development of a CDK2-docking site peptide that inhibits p53 and sensitizes cells to death: M. Ferguson, et al.; Cell Cycle
3, 80 (2004),
Abstract;
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles: C.E. Arris, et al.; J. Med. Chem.
43, 2797 (2000),
Abstract;
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