Product Details
Alternative Name: | SYN2 |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to a portion of rat Synapsin II. The sequence is completely conserved in mouse. |
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UniProt ID: | Q63537 |
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Gene/Protein Identifier: | C30411 (PIR) |
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Source: | Purified from rabbit serum. |
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Species reactivity: | Mouse, Rat
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Applications: | IP, WB
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Recommended Dilutions/Conditions: | Immunoprecipitation (1:100) Western Blot (1µg/ml, colorimetric) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~74kDa (synapsin Iia) and ~54kDa (synapsin Iib) by Western blot. |
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Purity Detail: | Protein A affinity purified. |
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Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Synapsin I, II and III belong to a family of neuron-specific phosphoproteins which maintain a reserve pool of vesicles in the vicinity of the active zone by tethering synaptic vesicles to each other and to an Actin-based cytoskeleton meshwork. They have been shown to regulate neurotransmitter release in mature synapses and to accelerate development of the nervous system. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L: E. Coccia, et al.; Cell Death Dis.
11, 82 (2020),
Abstract;
Full Text
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