SAP97 monoclonal antibody (RPI 197.4)



ADI-VAM-PS005-D	50 µg	243.00 USD

ADI-VAM-PS005-F	200 µg	515.00 USD
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Product Details

Alternative Name:	Synapse-associated protein 97, Disks large homolog 1

Clone:	RPI 197.4

Host:	Mouse

Isotype:	IgG1

Immunogen:	Recombinant rat SAP97 (N-terminal fragment).

UniProt ID:	Q62696

Source:	Purified from ascites.

Species reactivity:	Human, Mouse, Rat Dog

Applications:	ICC, IHC, IP, WB Electron microscopy

Recommended Dilutions/Conditions:	Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Application Notes:	Detects bands of ~97kDa and ~140kDa by Western blot.

Purity Detail:	Protein G affinity purified.

Formulation:	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.

Shipping:	Blue Ice

Long Term Storage:	-20°C

Scientific Background:	Synapse-associated proteins SAP97 and SAP102 display extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminals. In addition to the CNS, SAP97 is also detected at the basal lateral membrane between a variety of epithelial cells. SAP102 associates with NMDA receptors through the C-terminal NR2B subunit of the receptor. The N-terminal SAP97 PDZ domain mediates its interaction with the synaptic ras-GTPase activating protein SynGAP.

Regulatory Status:	RUO - Research Use Only

SAP97 monoclonal antibody (RPI 197.4) Western blot

Western blot analysis: Lane 1: MW marker, Lane 2: Rat Brain Tissue Extract, Lane 3: Mouse Brain Tissue Extract.

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Product Literature References

Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals: G. Cencelli, et al.; Cell. Mol. Life Sci. 12, 758 (2023), Abstract;

Analysis of mRNA and Protein Levels of CAP2, DLG1 and ADAM10 Genes in Post-Mortem Brain of Schizophrenia, Parkinson’s and Alzheimer’s Disease Patients: A.D. Maio, et al.; Int. J. Mol. Sci. 23, 1539 (2022), Abstract;

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model: G. Lordén, et al.; Nat. Commun. 13, 7200 (2022), Abstract;

Involvement of PDZ-SAP97 Interactions in Regulating AQP2 Translocation in Response to Vasopressin in LLC-PK1 cells: M.M. Nooh, et al.; Am. J. Physiol. Renal Physiol. 317, F375 (2019), Abstract;

Modulatory effect of acetyl-L-carnitine on amyloid precursor protein metabolism in hippocampal neurons: M. Di Luca, et al. ; Eur. J. Pharmacol. 597, 51 (2008), Application(s): WB using human cell lysates, Abstract;

A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia: B. Margolis, et al. ; Mol. Cell. Biol. 22, 1778 (2002), Application(s): IP, ICC, WB using canine samples, Abstract;

Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97: J. Marshall, et al. ; J. Biol. Chem. 276, 16092 (2001), Application(s): WB using human & rat samples, Abstract;

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