Product Details
| Alternative Name: | Amyloid A4 protein, Amyloid protein |
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| Clone: | 3E9 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Synthetic peptide corresponding to a portion of human APP695. |
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| UniProt ID: | P05067 |
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| Species reactivity: | Human, Mouse
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (5-10µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~102kDa by Western blot. |
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS pH7.2 containing 50% glycerol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Deposition of APP (Amyloid A4 protein) precursor intraneuronally as neurofibrillary tangles, extracellularly as plaques, and in blood vessels, is characteristic of both Alzheimers disease and aged Downs Syndrome. There are five forms of APP: APP395, APP563, APP695, APP751, and APP770. They are produced by alternative splicing of the APP gene. APP695 is the most predominant form in neuronal tissue while APP751 is the predominant form found elsewhere. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of Amyloid Precursor Protein expression in mouse brain using APP mAb (3E9).
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Product Literature References
Caspase-8, association with Alzheimer’s Disease and functional analysis of rare variants: J. Rehker, et al.; PLoS One
12, e0185777 (2017),
Abstract;
Full Text
Astrocytes regulate α-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: Involvement of group IIA secretory phospholipase A2: X. Yang, et al.; Neuroscience
300, 508 (2015),
Application(s): Immunofluorescence,
Abstract;
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