Product Details
Host: | Rabbit |
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Immunogen: | Phosphoserine conjugated to KLH. |
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Species reactivity: | Species independent
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Applications: | ELISA, IHC, IP, WB
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Recommended Dilutions/Conditions: | ELISA (1µg/ml) Immunohistochemistry (5µg/ml) Immunoprecipitation (10µg/mg protein) Western Blot (1µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Purity Detail: | Peptide affinity purified. |
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Formulation: | Liquid. In PBS with 50% glycerol. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Protein phosphorylation is a complex biochemical process that is regulated by protein kinases that catalyze the transfer of the gamma-P of ATP to a recipient protein that acts as a substrate. This post-translational modification is primarily directed onto serine, threonine, and tyrosine amino acid residues within a protein. Changes in the phosphorylation status of phosphoproteins can alter their biological function, and aberrations in signal transduction cascades have been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders. |
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Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of human MMRU melanoma cells probed with Phosphoserine, pAb. Top (from the left): MMRU cells treated with 0 (A), 50 (B), 200 (C), 400 (D) l long wavelength UV, or 0.1µM of okadaic acid (E). Bottom: Same samples probed with β-actin antibody (control).
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Product Literature References
Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells: J. Liu, et al. ; Gynecol. Oncol.
105, 23 (2007),
Application(s): WB, IP using xenopus tissue,
Abstract;
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