Product Details
| Alternative Name: | Proto-oncogene c-Src, pp60c-src |
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| Clone: | 5A18 |
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| Host: | Mouse |
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| Immunogen: | Recombinant human full length c-Src. |
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| UniProt ID: | P12931 |
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| Source: | Purified from hybridoma tissue culture supernatant. |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | IHC (PS), WB
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| Recommended Dilutions/Conditions: | Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~60kDa by Western blot. |
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Src is a member of the tyrosine kinase family that was originally identified as the oncogene of Rous sarcoma virus. The catalytic domain contains a tyrosine autophosphorylation site that increases kinase activity when phosphorylated. The Src family of tyrosine kinase is involved in a variety of receptor-induced signal transduction pathways such as immune recognition rec |
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| Regulatory Status: | RUO - Research Use Only |
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IHC Analysis: Human adrenal tissue stained with Src, mAb (5A18) at 20µg/ml.
Western blot analysis of Src using 20µg of whole cell lysate (Lane 2=HeLa, Lane 3=3T3, Lane 4=PC12) probed with with Src, mAb (5A18) at 1µg/ml.
IHC Analysis: Human prostate tissue stained with Src, mAb (5A18) at 20µg/ml.
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Product Literature References
Niclosamide Suppresses Migration and Invasion of Human Osteosarcoma Cells by Repressing TGFBI Expression via the ERK Signaling Pathway: L.T. Yeh, et al.; Int. J. Mol. Sci.
23, 484 (2022),
Abstract;
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