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Posttranslational Modifications

Posttranslational Modifications

Protein synthesis, folding, and post-translational modifications are of vital importance in proteomic studies of biological systems. Evaluation of protein homeostasis (proteostasis) extends beyond translation to involve assisted folding by molecular chaperones and chemical modification to achieve a protein’s native conformation. Further, a multitude of chemical modifications (e.g. phosphorylation, ubiquitinylation, acetylation, glycosylation, SUMOylation, and methylation) are utilized to regulate proper localization and function. Enzo Life Sciences’ extensive range of chaperone and post-translational modification reagents facilitates detailed characterization of these mechanisms of proteostasis.

 

Histone Post-translational Modifications

Solutions For Screening Epigenetic Regulators

For over a decade, the FLUOR DE LYS® deacetylase assay platform has freed researchers from cumbersome protocols for screening HDAC & Sirtuin activity. Our high-quality chemiluminescent, fluorescent, and colorimetric assays deliver more high-quality hits, and are backed by a broad panel of characterized inhibitors and PTM-specific antibodies for ubiquitinylation, sumoylation, methylation, acetylation, and phosphorylation.

 

Active Enzymes & Drug Discovery Assays

Convenient screening formats, featuring Fluor de Lys HDAC & Sirtuin assays, transferase & demethylase assays, and high-activity enzymes.

Small Molecules & Compound Libraries

Benchmark against known epigenetic modulators.

PTM-specific Antibodies

Detect acetylation, methylation, ubiquitinylation and more with high-quality antibodies backed by our Worry-Free program.

Ubiquitin & UBL Signaling

Solutions For Screening Epigenetic Regulators

Browse hundreds of high-quality research products, including proteins and antibodies, for activating enzymes (E1s), conjugating enzymes (E2s), ligases (E3s) and deconjugating enzymes (DCEs), plus an innovative range of ubiquitin-, SUMO-, NEDD8-, ISG15- and FAT10-associated proteins and derivatives. Discover ubiquitin- and Ubl-reactive antibodies, kits for the study of ubiquitin, SUMO, and NEDD8 conjugation, and our easy-to-use UBIQAPTURE™ and SUMO-QAPTURE™ kits for the detection and isolation of ubiquitinylated and SUMOylated proteins.

 

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