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Serine Proteases and Cancer

Novel Serine Protease Cancer Biomarker Products

Enzo Life Sciences offers more than 40 unique serine protease related products specifically related to cancer biomarker discovery, with emphasis on key family members identified as markers of early stage ovarian, breast, prostate and lung cancer (see table).

  • High-sensitivity, easy-to use and rapid ELISA kits
  • Ready-to-user proteins for use as ELISA or Western blot standards
  • Exclusive antibodies created against native proteins

Serine Proteases as Cancer Biomarkers

Serine proteases (or serine endopeptidases) are enzymes that breakdown proteins in extracellular compartments by cleavage of peptide bonds in the proteins. There are at least 14 family members found ubiquitously in both eukaryotes and prokaryotes. In humans, they are responsible for coordinating various physiological functions including digestion, immune response, blood coagulation and reproduction. Dysfunction often leads to human diseases and disorders, and mutations may lead to decreased or increased enzymatic activity. In cancer, serine proteases mediate a variety of events relevant to fundamental processes of tumor invasion and metastasis. In ovarian cancer, they are thought to promote tumor growth and dissemination, and their production can be detected early in tumor formation. The link between serine protease functions and cancer outcomes suggests that they may be a suitable target for therapeutic agents aimed at prevention of tumor progression and metastasis. As a tumor biomarker, serine proteases hold promise as a means of identifying certain cancers at an earlier stage to guide treatment and improve outcome.

Featured Products

  • Rapid results in just 3 hours from up to 40 samples in duplicate
  • Sensitive assay measures as little as 0.2 U/ml of hepsin
  • Fully quantitative results surpass semi-quantitative Western blot analysis
Western blot analysis of recombinant human Matriptase (30KD) (Prod. no. ADI-908-301) using Matriptase, mAb (D11) (Prod. no. ADI-905-1008) (lane 2) or Matriptase, mAb (B12) (Prod. no. ADI-905-1007) (lane 3).
 

ELISAs

Kallikrein-6 (human), ELISA kit 

Rapid ELISA kit to quantify kallikrein-6, a serine protease and unique cancer biomarker
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-217-0001 96 wells 589.00 USD
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Kallikrein-7 (human), ELISA kit 

Rapid ELISA kit to quantify kallikrein-7, a serine protease and unique cancer biomarker
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-218-0001 96 wells 589.00 USD
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Kallikrein-8 (human), ELISA kit 

Highly sensitive, rapid ELISA kit to quantify kallikrein-8, a serine protease and unique cancer biomarker.
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-219-0001 96 wells 589.00 USD
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Hepsin (human), ELISA Kit 

Rapid ELISA kit to quantify hepsin, a serine protease and unique cancer biomarker.
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-220-0001 96 wells 589.00 USD
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Matriptase (human), ELISA kit 

Sensitive, rapid ELISA kit to quantify matriptase, a serine protease and unique cancer biomarker.
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-221-0001 96 wells 599.00 USD
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SLPI (human), ELISA kit 

Rapid ELISA kit to quantify SLPI, a secretory leukocyte peptidase inhibitor and unique cancer biomarker.
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-222-0001 96 wells 589.00 USD
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Proteins

Kallikrein-8 (human), (recombinant) (His-tag) 

Produced in insect cells. Human recombinant KLK8 (aa 24-260) is fused to a His-tag. Produced in a baculovirus expression system., ≥90% (SDS-PAGE), ELISA, WB | Print as PDF
 
ADI-908-300-0010 10 µg 310.00 USD
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Matriptase (human), (recombinant) (His-tag) 

Produced in insect cells. Human recombinant matriptase (aa 619-854) is fused to a His-tag. Produced in a baculovirus expression system. , ≥90% (SDS-PAGE), WB, in vitro Assay | Print as PDF
 
ADI-908-301-0010 10 µg 310.00 USD
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Kallikrein-7 (human), (recombinant) (His-tag) 

Produced in insect cells. Human recombinant KLK7 (aa 21-253) is fused to a His-tag. Produced in a baculovirus expression system. , ≥90% (SDS-PAGE), ELISA, WB | Print as PDF
 
ADI-908-302-0010 10 µg 299.00 USD
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SLPI (human), (recombinant) (His-tag) 

Produced in insect cells. Human recombiinant SLPI (aa 25-132) is fused to a His-tag. Produced in a baculovirus expression system., ≥90% (SDS-PAGE), WB, in vitro Assay | Print as PDF
 
ADI-908-304-0010 10 µg 299.00 USD
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Kallikrein-6 (human), (recombinant) (His-tag) 

Produced in insect cells. Human recombinant KLK6 (aa 17-244) is fused to a His-tag. Produced in a baculovirus expression system., ≥90% (SDS-PAGE), ELISA, WB | Print as PDF
 
ADI-908-305-0010 10 µg 299.00 USD
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Antibodies

Kallikrein-8 monoclonal antibody (BE) 

ELISA, WB | Print as PDF
 
ADI-905-1000-0100 100 µg 399.00 USD
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Kallikrein-8 monoclonal antibody (BCB) 

ELISA | Print as PDF
 
ADI-905-1001-0100 100 µg 399.00 USD
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Kallikrein-8 monoclonal antibody (CGA) 

ELISA | Print as PDF
 
ADI-905-1002-0100 100 µg 399.00 USD
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Kallikrein-8 monoclonal antibody (AJE) 

ELISA | Print as PDF
 
ADI-905-1003-0100 100 µg 399.00 USD
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Kallikrein-8 monoclonal antibody (D2) 

ELISA | Print as PDF
 
ADI-905-1004-0100 100 µg 399.00 USD
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Kallikrein-8 monoclonal antibody (B12) 

ELISA, WB | Print as PDF
 
ADI-905-1005-0100 100 µg 399.00 USD
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Matriptase monoclonal antibody (C12) 

ELISA, WB | Print as PDF
 
ADI-905-1006-0100 100 µg 399.00 USD
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Matriptase monoclonal antibody (B12) 

ELISA, WB | Print as PDF
 
ADI-905-1007-0100 100 µg 399.00 USD
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Matriptase monoclonal antibody (D11) 

ELISA, WB | Print as PDF
 
ADI-905-1008-0100 100 µg 399.00 USD
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Kallikrein-7 monoclonal antibody (B12) 

ELISA, WB | Print as PDF
 
ADI-905-1009-0100 100 µg 399.00 USD
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Kallikrein-7 monoclonal antibody (E3) 

ELISA, WB | Print as PDF
 
ADI-905-1010-0100 100 µg 399.00 USD
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Kallikrein-7 monoclonal antibody (F7) 

ELISA, WB | Print as PDF
 
ADI-905-1011-0100 100 µg 399.00 USD
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Kallikrein-7 monoclonal antibody (F8) 

ELISA, WB | Print as PDF
 
ADI-905-1012-0100 100 µg 399.00 USD
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SLPI monoclonal antibody (D12) 

ELISA, WB | Print as PDF
 
ADI-905-1014-0100 100 µg 399.00 USD
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SLPI monoclonal antibody (A2) 

ELISA, WB | Print as PDF
 
ADI-905-1015-0100 100 µg 399.00 USD
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SLPI monoclonal antibody (F6) 

ELISA, WB | Print as PDF
 
ADI-905-1016-0100 100 µg 399.00 USD
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SLPI monoclonal antibody (H5) 

ELISA, WB | Print as PDF
 
ADI-905-1017-0100 100 µg 399.00 USD
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SLPI monoclonal antibody (C10) 

ELISA, WB | Print as PDF
 
ADI-905-1018-0100 100 µg 399.00 USD
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SLPI monoclonal antibody (A10) 

ELISA, WB | Print as PDF
 
ADI-905-1019-0100 100 µg 399.00 USD
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Kallikrein-6 monoclonal antibody (E2) 

ELISA, WB | Print as PDF
 
ADI-905-1020-0100 100 µg 399.00 USD
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Kallikrein-6 monoclonal antibody (E3) 

ELISA, WB | Print as PDF
 
ADI-905-1021-0100 100 µg 399.00 USD
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Kallikrein-6 monoclonal antibody (G9) 

ELISA, WB | Print as PDF
 
ADI-905-1022-0100 100 µg 399.00 USD
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Kallikrein-6 monoclonal antibody (F7) 

ELISA, WB | Print as PDF
 
ADI-905-1023-0100 100 µg 399.00 USD
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Kallikrein-6 monoclonal antibody (A3) 

ELISA, WB | Print as PDF
 
ADI-905-1024-0100 100 µg 399.00 USD
Do you need bulk/larger quantities?
 

Hepsin monoclonal antibody (E4) 

ELISA, WB | Print as PDF
 
ADI-905-1025-0100 100 µg 399.00 USD
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Hepsin monoclonal antibody (F5) 

ELISA, WB | Print as PDF
 
ADI-905-1026-0100 100 µg 399.00 USD
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Hepsin monoclonal antibody (G8) 

ELISA, WB | Print as PDF
 
ADI-905-1027-0100 100 µg 399.00 USD
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TMPRSS3 monoclonal antibody (E7) 

ELISA, WB | Print as PDF
 
ADI-905-1028-0100 100 µg 399.00 USD
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TMPRSS3 monoclonal antibody (D8) 

ELISA, WB | Print as PDF
 
ADI-905-1029-0100 100 µg 399.00 USD
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