Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Dexamethasone

Glucocorticoid receptor ligand
 
BML-EI126-0001 1 g 68.00 USD
 
BML-EI126-0005 5 g 270.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-370-002

Anti-inflammatory glucocorticoid with anti-inflammatory activity. Induces the production of phospholipase A2 inhibitory protein (lipocortin). Inhibits induction of nitric oxide synthase (NOS) (IC50=5nM). Induces apoptosis in eosinophils, but inhibits it in neutrophils. Both effects are blocked by RU-486. Modulates osteogenesis of mesenchymal stem cells. Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Oral dexamethasone administration induces an increase in insulin resistance in humans. Furthermore, it inhibits differentiation of immature to mature dendritic cells.

Product Specification

Alternative Name:9α-Fluoro-16α-methylprednisolone
 
Formula:C22H29FO5
 
MW:392.5
 
CAS:50-02-2
 
MI:14: 2943
 
RTECS:TU3980000
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (25mg/ml), 100% ethanol (25mg/1.6ml) or methanol; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for up to 5 years after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light.
 
bml-ei126
Please mouse over
bml-ei126

Product Literature References

Local release of dexamethasone from macroporous scaffolds accelerates islet transplant engraftment by promotion of anti-inflammatory M2 macrophages: K. Jiang, et al.; Biomaterials 114, 71 (2017), Abstract;
Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics: J. Zhang, et al. ; Biomaterials 70, 37 (2015), Application(s): Cell Culture, Abstract;
Reconfigurable Hybrid interface for molecular marker diagnostics and in-situ reporting: K. Ehrhardt, et al.; Biosens. Bioelectron. 74, 744 (2015), Application(s): Cell Culture, Abstract;
Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy: U. Grohmann, et al.; Nature Medicine 13, 579 (2007), Abstract;
Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles: S.C. Schafer, et al.; Am. J. Physiol. Heart Circ. Physiol. 288, H436 (2005), Abstract; Full Text
Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-kappaB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line: A.L. Vital, et al.; Mediators Inflamm. 12, 71 (2003), Abstract;
Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells: J. Shinoda, et al.; Glia 42, 68 (2003), Abstract;
Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages: R. Korhonen, et al.; Mol. Pharmacol. 62, 698 (2002), Abstract; Full Text
Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells: M. Matsumura, et al.; Life Sci. 69, 1067 (2001), Abstract;
Dexamethasone inhibits the phosphorylation of retinoblastoma protein in the suppression of human vascular smooth muscle cell proliferation: T.D. Reil, et al.; J. Surg. Res. 92, 108 (2000), Abstract;
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone: T. Biswas, et al.; Oncogene 18, 525 (1999), Abstract;
Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2: M.S. Montani, et al.; Cell Death Differ. 6, 79 (1999), Abstract;
Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases: M.G. Cifone, et al.; Blood 93, 2282 (1999), Abstract; Full Text
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes: T. Grombacher, et al.; Carcinogenesis 17, 2329 (1996), Abstract;
Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes: L.C. Meagher, et al.; J. Immunol. 156, 4422 (1996), Abstract;
Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle: H.O. Fearnhead, et al.; Biochem. Pharmacol. 48, 1073 (1994), Abstract;
Dexamethasone inhibits the expression of an inducible nitric oxide synthase in infarcted rabbit myocardium: R.R. Dudek, et al.; BBRC 202, 1120 (1994), Abstract;
Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells: C. Estrada, et al.; BBRC 186, 475 (1992), Abstract;
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells: K.J. O'Connor & S. Moncada; Biochim. Biophys. Acta 1097, 227 (1991), Abstract;
Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects?: S. Moncada & R.M.J. Palmer; TIPS 12, 130 (1991), (Review), Abstract;
Differential effects of aspirin and dexamethasone on phospholipase A2 and C activities and arachidonic acid release from endothelial cells in response to bradykinin and leukotriene D4: M.A. Clark, et al.; Prostaglandins 32, 703 (1986), Abstract;
Dexamethasone-induced insulin resistance enhances B cell responsiveness to glucose level in normal men.: J.C. Beard; Am. J. Physiol. 247, E592 (1984), Abstract;

Related Products

Compound A 

Glucocorticoid receptor modulator
14593-25-0, ≥98% (HPLC) | Print as PDF
 
ALX-550-516-M005 5 mg 53.00 USD
 
ALX-550-516-M025 25 mg 133.00 USD
Do you need bulk/larger quantities?
 

Related Literature

Brochures
Stem Cells
Stem Cells
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,