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Glucocorticoid receptor ligand
BML-EI126-0001 1 g 68.00 USD
BML-EI126-0005 5 g 270.00 USD
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Replaces Prod. #: ALX-370-002

Anti-inflammatory glucocorticoid with anti-inflammatory activity. Induces the production of phospholipase A2 inhibitory protein (lipocortin). Inhibits induction of nitric oxide synthase (NOS) (IC50=5nM). Induces apoptosis in eosinophils, but inhibits it in neutrophils. Both effects are blocked by RU-486. Modulates osteogenesis of mesenchymal stem cells. Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Oral dexamethasone administration induces an increase in insulin resistance in humans. Furthermore, it inhibits differentiation of immature to mature dendritic cells.

Product Specification

Alternative Name:9α-Fluoro-16α-methylprednisolone
MI:14: 2943
Purity:≥98% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (25mg/ml), 100% ethanol (25mg/1.6ml) or methanol; insoluble in water.
Long Term Storage:Ambient
Use/Stability:Stable for up to 5 years after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light.
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Product Literature References

Local release of dexamethasone from macroporous scaffolds accelerates islet transplant engraftment by promotion of anti-inflammatory M2 macrophages: K. Jiang, et al.; Biomaterials 114, 71 (2017), Abstract;
Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics: J. Zhang, et al. ; Biomaterials 70, 37 (2015), Application(s): Cell Culture, Abstract;
Reconfigurable Hybrid interface for molecular marker diagnostics and in-situ reporting: K. Ehrhardt, et al.; Biosens. Bioelectron. 74, 744 (2015), Application(s): Cell Culture, Abstract;
Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy: U. Grohmann, et al.; Nature Medicine 13, 579 (2007), Abstract;
Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles: S.C. Schafer, et al.; Am. J. Physiol. Heart Circ. Physiol. 288, H436 (2005), Abstract; Full Text
Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-kappaB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line: A.L. Vital, et al.; Mediators Inflamm. 12, 71 (2003), Abstract;
Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells: J. Shinoda, et al.; Glia 42, 68 (2003), Abstract;
Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages: R. Korhonen, et al.; Mol. Pharmacol. 62, 698 (2002), Abstract; Full Text
Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells: M. Matsumura, et al.; Life Sci. 69, 1067 (2001), Abstract;
Dexamethasone inhibits the phosphorylation of retinoblastoma protein in the suppression of human vascular smooth muscle cell proliferation: T.D. Reil, et al.; J. Surg. Res. 92, 108 (2000), Abstract;
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone: T. Biswas, et al.; Oncogene 18, 525 (1999), Abstract;
Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2: M.S. Montani, et al.; Cell Death Differ. 6, 79 (1999), Abstract;
Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases: M.G. Cifone, et al.; Blood 93, 2282 (1999), Abstract; Full Text
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes: T. Grombacher, et al.; Carcinogenesis 17, 2329 (1996), Abstract;
Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes: L.C. Meagher, et al.; J. Immunol. 156, 4422 (1996), Abstract;
Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle: H.O. Fearnhead, et al.; Biochem. Pharmacol. 48, 1073 (1994), Abstract;
Dexamethasone inhibits the expression of an inducible nitric oxide synthase in infarcted rabbit myocardium: R.R. Dudek, et al.; BBRC 202, 1120 (1994), Abstract;
Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells: C. Estrada, et al.; BBRC 186, 475 (1992), Abstract;
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells: K.J. O'Connor & S. Moncada; Biochim. Biophys. Acta 1097, 227 (1991), Abstract;
Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects?: S. Moncada & R.M.J. Palmer; TIPS 12, 130 (1991), (Review), Abstract;
Differential effects of aspirin and dexamethasone on phospholipase A2 and C activities and arachidonic acid release from endothelial cells in response to bradykinin and leukotriene D4: M.A. Clark, et al.; Prostaglandins 32, 703 (1986), Abstract;
Dexamethasone-induced insulin resistance enhances B cell responsiveness to glucose level in normal men.: J.C. Beard; Am. J. Physiol. 247, E592 (1984), Abstract;

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