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Compound A

Glucocorticoid receptor modulator
ALX-550-516-M005 5 mg 67.00 USD
ALX-550-516-M025 25 mg 176.00 USD
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Cell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No. BML-EI126) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes in vivo.

Product Details

Alternative Name:CpdA, 2-((4-Acetophenyl)-2-chloro-N-methyl)ethylammonium chloride
Formula:C11H14ClNO2 . HCl
MW:227.7 . 36.5
Purity:≥98% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO, 100% ethanol or water.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-80°C
Use/Stability:Stock solutions in ethanol are stable for up to 1 month when stored at -80°C.
Handling:Protect from moisture. After reconstitution, prepare aliquots and store at -80°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Relative contribution of molecular mechanisms to cumulative ligand-mediated downregulation of GRα: L.L. Spies, et al.; Biochem. Biophys. Res. Commun. 602, 113 (2022), Abstract;
Glucocorticoids decrease the production of glucagon-like peptide-1 at the transcriptional level in intestinal l-cells: T. Sato, et al.; Mol. Cell Endocrinol. 406, 60 (2015), Application(s): Cell Culture, Assay, Abstract;
A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance: V. Gossye, et al.; Ann. Rheum. Dis. 69, 291 (2010), Abstract;
Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis: G. van LOO, et al.; Mol. Endocrinol. 24, 310 (2010), Abstract;
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis: P. Dewint, et al.; J. Immunol. 180, 2608 (2008), Abstract;
A fully dissociated compound of plant origin for inflammatory gene repression: K. De Bosscher, et al.; PNAS 102, 15827 (2005), Abstract;

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