Product Details
| Alternative Name: | INDO, Indoleamine 2,3-dioxygenase, Indole 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase |
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| Clone: | 2E2 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant mouse IDO1. |
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| UniProt ID: | P28776 |
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| Gene/Protein Identifier: | 15930 (Entrez GeneID) |
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| Species reactivity: | Mouse
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| Applications: | WB
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Scientific Background: | Indoleamine 2,3-dioxygenase (IDO) is an IFN-γ inducible gene. It catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. IDO has been implicated to protect against intracellular and extracellular pathogens. . IDO1 is also known as Indolamine 2,3-dioxygenase, Indole 2,3-dioxygenase, and Indoleamine-pyrrole 2,3-dioxygenase. IDO is a ubiquitously expressed cytoplasmic protein with a predicted molecular weight of approximately 45 kDa. Indoleamine 2,3-dioxygenase (IDO) is one the best known IFN-γ inducible genes. The product of IDO gene catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. IDO has been implicated to protect against intracellular and extracellular pathogens. It also has been shown to maintain the special immune suppressive status of immune-privileged sites such as the brain, eyes, kidney, and placenta. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
IDO-1 inhibitor INCB24360 elicits distant metastasis of basal extruded cancer cells in pancreatic ductal adenocarcinoma: H. Buhe, et al.; Acta Pharmacol. Sin.
44, 1277 (2023),
Abstract;
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine: C.C. Clement, et al.; Nat. Commun.
12, 4447 (2021),
Abstract;
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