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IDO1 (mouse) monoclonal antibody (mIDO-48)

ALX-804-901-0100 100 µg 262.00 USD
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Product Details

Alternative Name:INDO, Indoleamine 2,3-dioxygenase, Indole 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase
Immunogen:Recombinant mouse IDO1.
UniProt ID:P28776
Gene/Protein Identifier:15930 (Entrez GeneID)
Species reactivity:Mouse
Crossreactivity:Does not cross-react with IDO2 .
Application Notes:Cited applications include IHC.
Purity Detail:Affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:Indoleamine 2,3-dioxygenase (IDO) is an IFN-γ inducible gene. It catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. IDO has been implicated in protection against intracellular and extracellular pathogens. The mIDO-48 monoclonal antibody recognizes mouse IDO also known as Indolamine 2,3-dioxygenase, Indole 2,3-dioxygenase, and Indoleamine-pyrrole 2,3-dioxygenase. This antibody does not appear to react with human IDO. IDO is a ubiquitously expressed cytoplasm protein with a predicted molecular weight approximately 45 kDa. Indoleamine 2,3-dioxygenase (IDO) is one the best known IFN-γ inducible genes. The product of IDO gene catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. IDO has been implicated in protection against intracellular and extracellular pathogens. It also has been shown to maintain the special immune suppressive status of immune-privileged sites such as the brain, eyes, kidney, and placenta. The IDO antibody has been shown to be useful for western blotting and Immunohistochemistry.
Regulatory Status:RUO - Research Use Only

Product Literature References

IDO-1 inhibitor INCB24360 elicits distant metastasis of basal extruded cancer cells in pancreatic ductal adenocarcinoma: H. Buhe, et al.; Acta Pharmacol. Sin. 44, 1277 (2023), Abstract;
T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1: M. Trad, et al.; Biomed Res. Int. 2015, 891236 (2015), Application(s): Western Blot, Abstract; Full Text
Apicomplexan parasite, Eimeria falciformis, co-opts host tryptophan catabolism for life cycle progression in mouse: M. Schmidt, et al.; J. Biol. Chem. 287, 20197 (2012), Abstract;
F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation: A. Babich, et al.; J. Cell Biol. 197, 775 (2012), Abstract; Full Text
Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO: T.L. Sumpter, et al.; J. Immunol. 189, 3848 (2012), Abstract;
Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate: A.J. Muller, et al.; Cancer Res. 70, 1845 (2010), Application(s): Western Blot, Abstract; Full Text
Indoleamine 2,3-dioxygenase tissue distribution and cellular localization in mice: implications for its biological functions: X. Dai and B.T. Zhu; J. Histochem. Cytochem. 58, 17 (2010), Application(s): Western blot, Abstract; Full Text
Plasmacytoid dendritic cells prevent cigarette smoke and Chlamydophila pneumoniae-induced Th2 inflammatory responses: R. Sorrentino, et al.; Am. J. Respir. Cell Mol. Biol. 43, 422 (2010), Application(s): Immunohistochemistry, Western Blot, Abstract; Full Text
Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis: L. Harrington, et. al.; Infect. Immun. 76, 3045 (2008), Application(s): Immunohistochemistry, Abstract; Full Text

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