Product Details
| Alternative Name: | INDO, Indoleamine 2,3-dioxygenase, Indole 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase |
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| Clone: | mIDO-48 |
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| Host: | Rat |
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| Isotype: | IgG2b |
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| Immunogen: | Recombinant mouse IDO1. |
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| UniProt ID: | P28776 |
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| Gene/Protein Identifier: | 15930 (Entrez GeneID) |
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| Species reactivity: | Mouse
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| Crossreactivity: | Does not cross-react with IDO2 . |
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| Applications: | WB
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| Application Notes: | Cited applications include IHC. |
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| Purity Detail: | Affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Scientific Background: | Indoleamine 2,3-dioxygenase (IDO) is an IFN-γ inducible gene. It catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. IDO has been implicated in protection against intracellular and extracellular pathogens. The mIDO-48 monoclonal antibody recognizes mouse IDO also known as Indolamine 2,3-dioxygenase, Indole 2,3-dioxygenase, and Indoleamine-pyrrole 2,3-dioxygenase. This antibody does not appear to react with human IDO. IDO is a ubiquitously expressed cytoplasm protein with a predicted molecular weight approximately 45 kDa. Indoleamine 2,3-dioxygenase (IDO) is one the best known IFN-γ inducible genes. The product of IDO gene catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. IDO has been implicated in protection against intracellular and extracellular pathogens. It also has been shown to maintain the special immune suppressive status of immune-privileged sites such as the brain, eyes, kidney, and placenta. The IDO antibody has been shown to be useful for western blotting and Immunohistochemistry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
IDO-1 inhibitor INCB24360 elicits distant metastasis of basal extruded cancer cells in pancreatic ductal adenocarcinoma: H. Buhe, et al.; Acta Pharmacol. Sin.
44, 1277 (2023),
Abstract;
T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1: M. Trad, et al.; Biomed Res. Int.
2015, 891236 (2015),
Application(s): Western Blot,
Abstract;
Full Text
Apicomplexan parasite, Eimeria falciformis, co-opts host tryptophan catabolism for life cycle progression in mouse: M. Schmidt, et al.; J. Biol. Chem.
287, 20197 (2012),
Abstract;
F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation: A. Babich, et al.; J. Cell Biol.
197, 775 (2012),
Abstract;
Full Text
Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO: T.L. Sumpter, et al.; J. Immunol.
189, 3848 (2012),
Abstract;
Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate: A.J. Muller, et al.; Cancer Res.
70, 1845 (2010),
Application(s): Western Blot,
Abstract;
Full Text
Indoleamine 2,3-dioxygenase tissue distribution and cellular localization in mice: implications for its biological functions: X. Dai and B.T. Zhu; J. Histochem. Cytochem.
58, 17 (2010),
Application(s): Western blot,
Abstract;
Full Text
Plasmacytoid dendritic cells prevent cigarette smoke and Chlamydophila pneumoniae-induced Th2 inflammatory responses: R. Sorrentino, et al.; Am. J. Respir. Cell Mol. Biol.
43, 422 (2010),
Application(s): Immunohistochemistry, Western Blot,
Abstract;
Full Text
Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis: L. Harrington, et. al.; Infect. Immun.
76, 3045 (2008),
Application(s): Immunohistochemistry,
Abstract;
Full Text
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