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LRRC32 (human):Fc (human), (recombinant)

 
ALX-522-117-C050 50 µg 402.00 USD
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Product Specification

Alternative Name:Leucine-rich repeat-containing protein 32, GARP, Garpin, Glycoprotein A repetitions predominant
 
MW:104kDa (observed)
 
Source:Produced in CHO cells. Human LRRC32 (aa 20-627) is fused to the Fc portion of human IgG1.
 
UniProt ID:Q14392
 
Concentration:1mg/ml (after reconstitution).
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥90% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Cape Cod Associates).
 
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Scientific Background: LRRC32 (leucine rich repeat containing 32; also known as GARP or Garpin; Glycoprotein A repetitions predominant) is a glycoprotein expressed on the cell surface of megakaryocytes, platelets and activated regulatory T (Treg) cells.
 
ALX-522-117 SDS-PAGE
SDS-PAGE analysis: Lane 1: MW Marker, Lane 2: 2µg LRRC32 (human):Fc (human), (recombinant).
ALX-522-117 WB
Western Blot analysis: Lane 1: MW Marker, Lane 2: 100ng LRRC32 (human):Fc (human), (recombinant) probed with LRRC32 mAb (Prod. no. ALX-804-867).
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ALX-522-117 SDS-PAGE ALX-522-117 WB

General Literature References

GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells: D.Q. Tran et al.; PNAS 106, 13445 (2009), Abstract;
Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg: J. Stock et al.; Eur. J. Immunol. 39, 3315 (2009), Abstract;
Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression: R. Wang, et al.; PLoS ONE 3, e2705 (2008), Abstract; Full Text
Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins: I.C. Macaulay, et al.; Blood 109, 3260 (2007), Abstract;

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