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LRRC32 monoclonal antibody (Plato-1)

ALX-804-867-C100 100 µg 585.00 USD
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Product Details

Alternative Name:Leucine-rich repeat-containing protein 32, GARP, Garpin, Glycoprotein A repetitions predominant
Immunogen:Recombinant human LRRC32 (aa 20-627).  Detects a band of ~100kDa (Fc Fusion ALX-522-117)  by Western blot. Native protein is ~72kDa.
UniProt ID:Q14392
Source:Purified from concentrated hybridoma tissue culture supernatant.
Species reactivity:Human, Mouse
Applications:ELISA, IP, WB
Recommended Dilutions/Conditions:Immunoprecipitation (1:200)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Cited applications include flow cytometry.
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.02% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
Handling:For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Protect from light.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:LRRC32 (leucine rich repeat containing 32; also known as GARP or Garpin; Glycoprotein A repetitions predominant) is a glycoprotein expressed on the cell surface of megakaryocytes, platelets and activated regulatory T (Treg) cells.
Technical Info/Product Notes:1 test means: 1µl of MAb is used to stain 500’000 cells in a sample volume of 50µl.
Regulatory Status:RUO - Research Use Only

Product Literature References

Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism: M. Zhang, et al.; Signal Transduct. Target Ther. 6, 366 (2021), Abstract;
Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8: J. Stockis, et al.; PNAS 114, E10161 (2017), Abstract;
A key role of GARP in the immune suppressive tumor microenvironment: S.A. Hahn, et al.; Oncotarget 7, 42996 (2016), Application(s): Western blot, Abstract; Full Text
Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer: A. Metelli, et al.; Cancer Res. 76, 7106 (2016), Abstract; Full Text
Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells: C. Huygens, et al.; J. Biol. Chem. 290, 20105 (2015), Abstract; Full Text
Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency: M.M. Miller, et al.; AIDS Res. Hum. Retroviruses 29, 641 (2013), Application(s): Flow cytometry, Abstract; Full Text
GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells: E. Gauthy, et al.; PLoS One 8, e76186 (2013), Abstract; Full Text
Interleukin-21 (IL-21) synergizes with IL-2 to enhance T-cell receptor-induced human T-cell proliferation and counteracts IL-2/transforming growth factor-β-induced regulatory T-cell development: A. Battaglia, et al.; Immunology 139, 109 (2013), Application(s): Flow cytometry, Abstract; Full Text
CD4(+)CD25(+)Foxp3(+)IFNγ(+) Treg are immunosuppressive in vitro and increase with intensity of the alloresponse in pretransplant MLC: V. Daniel, et al.; Transpl. Immunol. 27, 114 (2012), Application(s): Flow cytometry, Abstract;
Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells: R. Wang, et al.; PNAS 106, 13439 (2009), Abstract;
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells: D.Q. Tran, et al.; PNAS 106, 13445 (2009), Abstract;
Therapeutic potential of FOXP3+ regulatory T cells and their interactions with dendritic cells: D.Q. Tran & E.M. Shevach; Hum. Immunol. 70, 294 (2009), Abstract;

General Literature References

Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression: R. Wang, et al.; PLoS ONE 3, e2705 (2008), Abstract; Full Text

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LRRC32 (human):Fc (human), (recombinant) 

Produced in CHO cells. Human LRRC32 (aa 20-627) is fused to the Fc portion of human IgG1., ≥90% (SDS-PAGE) | Print as PDF
ALX-522-117-C050 50 µg 514.00 USD
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