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Necrox-2™

Necrosis inhibitor
 
ALX-430-166-M001 1 mg 137.00 USD
 
ALX-430-166-M005 5 mg 472.00 USD
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Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1µM NecroX™-2 prevented ~50% cell death in H9C2 cells exposed to 400µM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro.

Product Specification

Alternative Name:[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine
 
Formula:C25H32N4O4S2
 
MW:516.7
 
Purity:≥95% (NMR, LCMS)
 
Appearance:Gray powder.
 
Solubility:Soluble in DMSO (>10mg/ml).
 
Application Notes:For in vitro applications, dissolve in DMSO to 20-50mM stock solution and dilute further in cell culture media. Treat cells with 30µM to 0.1µM final concentration.
Optimal conditions must be determined individually for each application.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
430-166
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430-166

Product Literature References

The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity: Q. Li, et al.; Nat. Commun. 6, 6183 (2015), Application(s): Cell Culture, Abstract;
Necrotic cell death in atherosclerosis: W. Martinet, et al.; Basic Res. Cardiol. 106, 749 (2011), Abstract;
NecroX as a novel class of mitochondrial reactive oxygen species and ONOO(-) scavenger: H.J. Kim, et al.; Arch. Pharm. Res. 33, 1813 (2010), Abstract;

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Necrosis inhibitor
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ALX-430-167-M001 1 mg 119.00 USD
 
ALX-430-167-M005 5 mg 360.00 USD
Do you need bulk/larger quantities?
 

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