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O-GlcNAcase inhibitor
ALX-380-010-M100 100 mg 47.00 USD
ALX-380-010-5100 5x100 mg 123.00 USD
ALX-380-010-G001 1 g 129.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: BML-EI138

Widely used diabetes inducer in rodents. Inhibition of β-cell O-GlcNAcase by streptozotocin is the mechanism that accounts for its diabetogenic toxicity. N-nitroso-containing antibiotic, acting as a nitric oxide (NO) donor and vasorelaxant. Relaxes phenylephrine-contracted aortic rings at 10µM. Potent methylating agent for DNA.

Product Specification

Alternative Name:Streptozocin, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose, STZ
MI:14: 8832
Purity:≥97% (Assay)
Appearance:White to pale yellow crystalline solid.
Solubility:Soluble in water (nH2O at 102.8mg/ml) or 100% ethanol (200 proof at 0.92mg/ml).
Shipping:Shipped on Dry Ice
Long Term Storage:-20°C
Use/Stability:Because solutions of the compound spontaneously give off NO gas at room temperature, we recommend that solutions be made immediately before use.
Technical Info/Product Notes:Solutions of Streptozotocin will spontaneously give off NO gas at room temperature. This NO release is slowed, but not completely stopped at -80°C, and the rate of NO release is also impacted by the solvent used (for example, dissolving Streptozotocin in buffers that contain sodium speeds up NO release).
 Since it does not seem to be possible to completely stop the NO release when streptozotocin is in solution, and the NO donor function is critical to the majority of experimental applications, we recommend that customers make solutions only immediately before use.
Note: since streptozotocin is often used to treat animals, the requirement that solutions be made immediately before use can be overwhelming for some users. Therefore, we generally suggest that the material be initially dissolved in ethanol, aliquoted into single use amounts, and then the alcohol evaporated off to produce dry aliquots. NO loss is minimized by doing this procedure with the material on ice, and carrying it out as quickly as possible. The individual dry aliquots can then be easily dissolved immediately before use.
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Product Literature References

Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes: J. Yu, et al.; Diabetologia 59, 2026 (2016), Application(s): Plasma lipoproteins permeation, Abstract; Full Text
Simvastatin enhances the hippocampal klotho in a rat model of streptozotocin-induced cognitive decline: S. Adeli, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 72, 87 (2016), Application(s): Drug administration to rats, Abstract;
A Lipidomic Screen of Hyperglycemia-Treated Human Retinal Endothelial Cells Links Lipid Metabolites of 12/15-Lipoxygenase to Microvascular Dysfunction during Diabetic Retinopathy via NADPH Oxidase: A.S. Ibrahim, et al.; J. Lipid Res. 56, 599 (2015), Application(s): Injection, Abstract; Full Text
Antiglycation and Hypolipidemic Effects of Polyphenols from Zingiber officinale Roscoe (Zingiberaceae) in Streptozotocin-Induced Diabetic Rats : M.I. Kazeem, et al.; Trop. J. Pharm. Res. 14, 55 (2015), Application(s): Injection, Full Text
Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of Securigera securidaca seeds in streptozotocin-induced diabetic rats: Z. Rajaei, et al.; Adv. Biomed. Res. 4, 33 (2015), Application(s): Injection, Full Text
Early Systemic Microvascular Damage in Pigs with Atherogenic Diabetes Mellitus Coincides with Renal Angiopoietin Dysbalance: M. Khairoun, et al.; PLoS One 10, e0121555 (2015), Application(s): Slow intravenous injection into pigs, Abstract; Full Text
Effects of Hydroalcoholic Extract of Watercress (Nasturtium Officinale) Leaves on Serum Glucose and Lipid Levels in Diabetic Rats: M.A. Hadjzadeh, et al.; Indian J. Physiol. Pharmacol. 59, 223 (2015), Application(s): Injection into rat, Abstract; Full Text
Elevation of cortical C26:0 due to the decline of peroxisomal β-oxidation potentiates amyloid β generation and spatial memory deficits via oxidative stress in diabetic rats: Y. Shi, et al.; Neuroscience 315, 125 (2015), Application(s): Intraperitoneally injected into rats, Abstract;
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids: A.S. Ibrahim, et al.; Biochim. Biophys. Acta. 1851, 290 (2015), Application(s): Injection, Abstract;
Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo: A.P. Johnston, et al.; Am. J. Physiol. Cell Physiol. 292, C1033 (2007), Abstract;
Genotoxicity of streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 512, 121 (2002), (Review), Abstract;
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas: T. Szkudelski; Physiol. Res. 50, 537 (2001), (Review), Abstract;
N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets: F.J. Bedoya, et al.; Experientia 52, 344 (1996), Abstract;
Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage: K.-D. Kroncke, et al.; Biol. Chem. Hoppe Seyler 376, 179 (1995), Abstract;
Nitric oxide generation from streptozotocin: N.S. Kwon, et al.; FASEB J. 8, 529 (1994), Abstract;
Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets: J. Turk, et al.; BBRC 197, 1458 (1993), Abstract;
NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta: K.C. Chang, et al.; BBRC 191, 509 (1993), Abstract;
Streptozotocin: a nitric oxide carrying molecule and its effect on vasodilation: G. Thomas & P. Ramwell; Eur. J. Pharmacol. 161, 279 (1989), Abstract;
Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice: H. Kolb; Diabetes Metab. Rev. 3, 751 (1987), Abstract;
Alkylation of DNA in rat tissues following administration of streptozotocin: R.A. Bennett & A.E. Pegg; Cancer Res. 41, 2786 (1981), Abstract;
The structure of streptozotocin: R.R. Herr, et al.; JACS 89, 4808 (1967), Abstract;
Studies on the diabetogenic action of streptozotocin: N. Rakieten, et al.; Cancer Chemother. Rep. 29, 91 (1963),

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