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Clofibrate

PPARα activator
 
ALX-270-256-M500 500 mg 16.00 USD
 
ALX-270-256-G001 1 g 35.00 USD
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Replaces Prod. #: BML-EI160

Activates PPARα. Induces cytochrome P450 4A1 and 4A3 which catalize the omega-oxidation of fatty acids and prostaglandins.

Product Specification

Alternative Name:2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
 
Formula:C12H15ClO3
 
MW:242.7
 
CAS:637-07-0
 
MI:14: 2377
 
Purity:≥98% (GC)
 
Appearance:Colorless oil.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Solutions are stable for up to 6 months when stored at –20°C.
 
ALX-270-256
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ALX-270-256

Product Literature References

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor: M. Göttlicher, et al.; PNAS 89, 4653 (1992), Abstract;
Effect of clofibrate treatment on hepatic prostaglandin catabolism and action: E.P. Brass & L.J. Ruff; J. Pharmacol. Exp. Ther. 257, 1034 (1991), Abstract;
Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha: T. Aoyama et al.; J. Lipid. Res. 31, 1477 (1990), Abstract;

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