Product Details
| Alternative Name: | SYT |
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| Clone: | ASV30 |
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| Host: | Mouse |
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| Isotype: | IgG2a |
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| Immunogen: | Rat brain synaptic junction protein complexes . |
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| UniProt ID: | P21707 |
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| GenBank ID: | X52772 |
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| Source: | Purified from mouse ascites. |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | IHC, WB
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| Recommended Dilutions/Conditions: | Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~65kDa by Western blot. |
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Synaptotagmins (Syt) are membrane-trafficking proteins characterized by an N-terminal transmembrane region, a variable linker, and two C-terminal C2-domains, C2A and C2B. At least twelve Synaptotagamins are expressed in vertebrates and can be found in both vesicular and plasma membranes. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of Synaptotagmin: Lane 1: MW marker, Lane 2: Mouse Brain Tissue Lysate (Prod No. ADI-LYT-MB100), Lane 3: Rat Brain Tissue Lysate (Prod No. ADI-LYT-RB100).
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Product Literature References
An ultra-stable cytoplasmic antibody engineered for in vivo applications: H. Kabayama, et al.; Nat. Commun.
11, 336 (2020),
Abstract;
Full Text
Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I: C.L. Schengrund, et al. ; J. Biol. Chem.
277, 32815 (2002),
Application(s): WB using human & mouse samples,
Abstract;
Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecterory tissue: W.D. Matthew, et al.; J. Cell Biol.
91, 257 (1981),
Application(s): WB, IHC using rat samples,
Abstract;
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