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Cannabinoid receptor CB1 polyclonal antibody

 
ADI-905-708-100 100 µg 301.00 USD
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Product Specification

Alternative Name:CB1, CNR1, CBR
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of mouse cannabinoid receptor CB1.
 
UniProt ID:P47746
 
Species reactivity:Human, Mouse, Rat
Chicken
 
Crossreactivity:Predicted species reactivity based on epitope sequence homology: gorilla, guinea pig, horse, dog, cat, platypus, Zebra Finch (bird).
 
Applications:ELISA, IHC, WB
 
Application Notes:Suitable for cell-based and membrane-based ELISA.
Predicted MW of ~53kDa. Higher MW species may also be observed by Western blot which reflect post-translational modification of the receptor.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
 
Handling:Keep on ice at all times.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The cannabinoid receptors CB1 and CB2 are GPCRs named for their signaling function in response to cannabinoid drugs such as Delta9-tetrahydrocannabinol (Delta9-THC). In addition to Delta9-THC and its synthetic analogs, CB1 and CB2 receptors are bound by endogenous eicosanoid ligands (e.g. anandamide), and signal via Gi/o alpha subunits to regulate adenylyl cyclase activity (generally inhibitory), ion channel activation, intracellular Ca2+ levels, nitric oxide synthase activation, and immediate early gene expression. CB1 and CB2 signals in turn regulate neurological and immunological functions such as inhibition of neurotransmitter release and immune cell migration, antigen processing, and cytokine production.
 
Manufacturer:Manufactured by Proteimax.
 
905-708 WB
Western blot analysis: MW Marker (1) and 10µg of rat brain membrane extract (2) probed with Cannabinoid Receptor (CB1) pAb at 2.8µg/ml.
905-708 m ELISA1
Membrane ELISA: Membranes (5µg) from rat striatum were treated with indicated concentrations of agonists (HU-210) and inverse agonist (SR141716A) and probed with Cannabinoid Receptor (CB1) pAb by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=3).
905-708 m ELISA2
Membrane ELISA: Lewis rat striatum membranes (5µg/well) were treated with 1 μM concentrations of agonist (HU210) and Inverse agonist (SR141716A/Hemopressin) and probed with Cannabinoid Receptor (CB1) pAb (1:1000 of a 1µg/μl stock solution) by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=2).
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905-708 WB 905-708 m ELISA1 905-708 m ELISA2

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