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PDGF receptor β monoclonal antibody (42G12)

 
ADI-905-682-100 100 µg 248.00 USD
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Product Specification

Alternative Name:PDGFR, platelet-derived growth factor receptor
 
Clone:42G12
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human PDGF Receptor β.
 
UniProt ID:P09619
 
Species reactivity:Mouse, Rat
 
Crossreactivity:Weakly cross-reacts with human PDGF receptor β.
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~125kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Mitogenic platelet derived growth factor (PDGF) signaling is mediated by the PDGF tyrosine kinase receptors PDGFRα and PDGFRβ, which exist as homo- or heterodimer isoforms (αα, ββ, αβ). Secretion of PDGFs and expression of PDGFRs in a broad distribution of cell types contributes to regulation of cellular processes including cell growth, actin reorganization, prevention of apoptosis, and chemotaxis. Structurally, the transmembrane PDGFRs are composed of an N-terminal extracellular domain with five immunoglobulin repeats, and an intracellular domain containing two spaced tyrosine kinase domains. PDGF ligands display preferential affinity to PDGFRα and PDGFRβ, with PDGFRβ activation restricted to binding by PDGF BB and PDGF DD. Growth factor binding initiates receptor dimerization and activates the cytosolic tyrosine kinase domains.
 
905-682 WB
Western blot analysis of MW marker (1) and mouse heart muscle lysate (2) probed with PDGF Receptor β mAb (42G12) (extra bands are secondary reactivity).
ADI-905-682 IHC1
IHC Analysis: Human placenta tissue stained with PDGF receptor β, mAb (42G12) at 20µg/ml.
ADI-905-682 IHC2
IHC Analysis: Human spleen tissue stained with PDGF receptor β, mAb (42G12) at 20µg/ml.
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905-682 WB ADI-905-682 IHC1 ADI-905-682 IHC2

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