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IL-17A (human), ELISA kit

 
ADI-900-177 96 wells 515.00 USD
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  • Ultra-Sensitive - detect as little as 0.201 pg/ml
  • Specific - negligible reactivity with other family members
  • Time Savings - results in just 3 hours!
  • Ready-to-use - pre-coated plates and liquid color-coded reagents reduce errors
A highly  sensitive competitive immunoassay for the measurement of IL-17A in human culture supernatants, serum and plasma samples. Results from up to 40 duplicate samples are read on a colorimetric plate reader at 450nm in just 3 hours.
ADI-900-177 std curve
Dose response curve of recombinant human IL-17A standard.
ADI-900-177 parallelism
Parallelism of the curves demonstrates that the antigen binding characteristics are similar enough to allow the accurate determination of native analyte levels in diluted samples of human origin.
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ADI-900-177 std curve ADI-900-177 parallelism

Product Specification

Alternative Name:Interleukin-17A, CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8
 
Sensitivity:0.2pg/ml (range 2.34-75pg/ml)
 
Assay Time:3 hours
 
Applications:ELISA, Colorimetric detection
 
Application Notes:For the quantitative determination of human IL-17A in culture supernatants, plasma, and serum samples.
 
Species reactivity:Human
 
Crossreactivity:Human IL-17A (100%) and <0.01%: human IL-17C and IL-17F
 
Quantity:1 x 96-well plate
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-20°C
 
Kit/Set Contains:Microtiter plate, Assay buffer 13, Standard, Antibody, Conjugate, Wash buffer concentrate, TMB substrate, Stop solution 2
 
Scientific Background:IL-17A is produced as a disulfide-linked homodimer that can also form heterodimers with IL-17F. IL-17 acts via ubiquitously expressed IL-17 receptors, inducing expression of pro-inflammatory factors such as IL-1, IL-6, TNF, CXCL8/IL-8, and matrix metalloproteinases. Elevated levels of IL-17A and increased presence of Th17 cells has been associated with airway inflammation, rheumatoid arthritis, intraperitoneal abscesses, inflammatory bowel disease, allograft rejection, psoriasis, multiple sclerosis, and cancer.
 
UniProt ID:Q16552
 

Product Literature References

Vitamin D supplementation for patients with multiple sclerosis treated with interferon-beta: a randomized controlled trial assessing the effect on flu-like symptoms and immunomodulatory properties: D. Golan, et al.; BMC Neurol. 13, 60 (2013), Application(s): ELISA using human serum, Abstract; Full Text

General Literature References

Th17 cells: from precursors to players in inflammation and infection: A. Awasthi & V.K. Kuchroo; Int. Immunol. 21, 489 (2009), Abstract;
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis: J.S. Tzartos, et al.; Am. J. Pathol. 172, 146 (2008), Abstract;
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage: L. Steinman; Nat. Med. 13, 139 (2007), Abstract;
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation: H. Kebir, et al.; Nat. Med. 13, 1173 (2007), Abstract;
Interleukin-17 family members and inflammation: J.K. Kolls & A. Linden; Immunity 21, 467 (2004), Abstract;
Increased expression of interleukin 17 in inflammatory bowel disease: S. Fujino, et al.; Gut 52, 65 (2003), Abstract;
Interleukin-17 family and IL-17 receptors: T.A. Moseley, et al.; Cytokine Growth Factor Rev. 14, 155 (2003), Abstract;
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene: E. Rouvier, et al.; J. Immunol. 150, 5445 (1993), Abstract;

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