| ENZ-ABS326-0100 | 100 µg | 570.00 USD |  |
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| Alternative Name: | Receptor-type tyrosine-protein phosphatase C |
| Clone: | PTPRC/1783R |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | Human B lymphocytes. |
| UniProt ID: | P08575 |
| Species reactivity: | Human |
| Applications: | Flow Cytometry, IF, IHC (PS), WB |
| Recommended Dilutions/Conditions: | Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL) Immunofluorescence (0.5-1 µg/mL) Immunohistology (formalin-fixed paraffin sections) (0.5-1 µg/mL) for 30 minutes at RT Western blot (0.5-1 µg/mL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin. This antigen is also expressed on the surface of cells of myeloid lineage. |
| Regulatory Status: | RUO - Research Use Only |
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