Specific non-chelating small-molecule inhibitor of MMP-12 (IC50 = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function.
Product Details
| Formula: | C25H20N2O3S |
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| MW: | 428.5 |
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| CAS: | 766536-21-4 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle apoptosis: H. Williams, et al.; Cardiovasc. Res.
87, 137 (2010),
Abstract;
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