Replaces Prod. #: ALX-380-055
Chromomycin A3 is a GC-specific DNA ligand which inhibits transcription. It may be used as a fluorescent DNA stain. Antibiotic. Cell permeable fluorescent dye that cann be used with Bisbenzimide H33258 to distinguish chromosomes by their total DNA concentration and their DNA base composition. Does not intercalate. Ex(max): 445nm; Em(max): 575nm
Product Details
| Formula: | C57H82O26 |
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| MW: | 1183.3 |
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| Source: | Isolated from Streptomyces griseus |
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| CAS: | 7059-24-7 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in 100% ethanol, DMSO or ethyl acetate (10mg/ml) |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells: S. Wong, et al.; Biochem. Pharmacol.
47, 827 (1994),
Abstract;
Selective accumulation of diamidino yellow and chromomycin A3 by retinal glial cells: C.-J. Jeon & R.H. Masland; J. Histochem. Cytochem.
41, 1651 (1993),
Abstract;
Specific staining of DNA with the fluorescent antibiotics, mithramycin, chromomycin, and olivomycin: H.A. Crissman & R.A. Tobey; Methods. Cell Biol.
33, 97 (1990),
Abstract;
Chromomycin A3 and its derivatives: K. Mizuno ; J. Antibiot. 16, 22 (1963),
