Replaces Prod. #: ALX-385-023
PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems. Inhibits cell growth and proliferation in acute myelogenous leukemia cell lines by causing cell arrest.
Product Details
Formula: | C16H13NO3 |
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MW: | 267.3 |
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CAS: | 167869-21-8 |
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Purity: | ≥95% (HPLC) |
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Appearance: | Pale yellow solid |
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Solubility: | Soluble in DMSO (6.5mg/ml); 25mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Handling: | Protect from light. |
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Technical Info/Product Notes: | Replacement for ADI-HPK-107 |
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Regulatory Status: | RUO - Research Use Only |
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