Inhibitor of NF-κB activation (induced by either PMA or TNF-α) in various cell types.
Product Details
| Alternative Name: | Ammoniumpyrrolidinedithiocarbamate, Ammoniumtetramethylenedithiocarbamate |
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| Formula: | C5H8NS2 . NH4 |
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| MW: | 146.3 . 18.0 |
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| CAS: | 5108-96-3 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to-off white solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Visfatin Promotes Monocyte Adhesion by Upregulating ICAM-1 and VCAM-1 Expression in Endothelial Cells via Activation of p38-PI3K-Akt Signaling and Subsequent ROS Production and IKK/NF-κB Activation: Y.T. Lin, et al.; Cell. Physiol. Biochem.
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Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells: A. Iseki, et al.; Biochem. Biophys. Res. Commun.
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Dual activity of pyrrolidine dithiocarbamate on kappaB-dependent gene expression in U937 cells: I. Regulation by the phorbol ester TPA: K. Watanabe, et al.; Cell Signal.
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Dual activity of pyrrolidine dithiocarbamate on kappaB-dependent gene expression in U937 cells: II. Regulation by tumour necrosis factor-alpha: K. Watanabe, et al.; Cell Signal.
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Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes: S.F. Liu, et al.; Circulation
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Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation: C.H. Kim, et al.; FEBS Lett.
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Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages: M.P. Sherman, et al.; BBRC
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