Na+/K+-and Mg2+-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. Modulates the Bcl-2 family. Shows antiplaque activity in humans.
Product Details
| Alternative Name: | Pseudochelerythrine |
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| Formula: | C20H14NO4Cl |
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| MW: | 367.8 |
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| Source: | Isolated from the leaves and stems of Macleaya cordata and M. microcarpa. |
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| CAS: | 5578-73-4 |
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| MI: | 14: 8356 |
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| RTECS: | VP5220000 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Orange solid. |
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| Solubility: | Soluble in methanol; slightly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt: M.H. Han, et al.; Anticancer Drugs
18, 913 (2007),
Abstract;
Metabolism of sanguinarine: the facts and the myths: Z. Dvorak & V. Simanek; Curr. Drug Metab.
8, 173 (2007), Review,
Abstract;
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol.
364, 538 (2006),
Abstract;
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol.
22, 439 (2006),
Abstract;
Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes: V.M. Adhami, et al.; Clin. Cancer Res.
9, 3176 (2003),
Abstract;
Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion: E. Debiton, et al.; Cancer Chemother. Pharmacol.
51, 474 (2003),
Abstract;
Sanguinarine, a new antiplaque agent: retention and plaque specificity: G.L. Southard, et al.; J. Am. Dent. Assoc.
108, 338 (1984),
Abstract;
Isoquinoline alkaloids. Inhibitory actions on cation-dependent ATP-phosphohydrolases: L.R. Meyerson, et al.; Neurochem. Res.
3, 239 (1978),
Abstract;
Sanguinarine, inhibitor of Na-K dependent ATP'ase: K.D. Straub & P. Carver; BBRC
62, 913 (1975),
Abstract;
