Replaces Prod. #: BML-EI226
A potent and selective inhibitor of protein kinase C (IC50=3.4µM). Anti-viral and anti-retroviral actitity. Displays antineoplastic and antitumor actitities. Most activities require light activation. Induces apoptosis in neuroblastoma cells at 1µM or above (IC50=0.1µM at 29 mW/cm2 (tungsten light)). Inhibitition of other kinases (e.g. EGFR-PTK, CKII and MAP kinase). Bright red fluorescence emissino and photostability. Antidepressant.
Product Details
| Formula: | C30H16O8 |
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| MW: | 504.4 |
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| Source: | Isolated from Hypericum perforatum. |
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| CAS: | 548-04-9 |
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| MI: | 14: 4863 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Dark brown to black-red powder. |
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| Solubility: | Soluble in DMSO (25mg/ml), 100% ethanol, methanol, acetone, ethylmethylketone, pyridine or other organic solvents and bases. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | High purity hypericin tautomerizes to 1,6-dioxo tautomer in the presence of water contained in solvents. |
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| Handling: | Protect from light and oxygen. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cellular mechanisms and prospective applications of hypericin in photodynamic therapy: T. Kiesslich, et al.; Curr. Med. Chem.
13, 2189 (2006), (Review),
Abstract;
Hypericin--the facts about a controversial agent: A. Kubin, et al.; Curr. Pharm. Des.
11, 233 (2005), (Review),
Abstract;
Hypericin--a new antiviral and antitumor photosensitizer: mechanism of action and interaction with biological macromolecules: P. Miskovsky; Curr. Drug Targets
3, 55 (2002), (Review),
Abstract;
Apoptotic and anti-apoptotic signaling pathways induced by photodynamic therapy with hypericin: P. Agostinis, et al.; Adv. Enzyme Regul.
40, 157 (2000),
Abstract;
Hypericin induces both differentiation and apoptosis in human promyelocytic leukemia HL-60 cells: K.T. Lee, et al.; Biol. Pharm. Bull.
22, 1271 (1999),
Abstract;
Over-expression of Bcl-2 does not protect cells from hypericin photo- induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway: R. Chaloupka, et al.; FEBS Lett.
462, 295 (1999),
Abstract;
The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin: Z. Assefa, et al.; J. Biol. Chem.
274, 8788 (1999),
Abstract;
Full Text
Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis: A. Vantieghem, et al.; FEBS Lett.
440, 19 (1998),
Abstract;
Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C: W. Zhang, et al.; Cancer Lett.
96, 31 (1995),
Abstract;
Novel therapeutic and diagnostic applications of hypocrellins and hypericins: Z. Diwu; Photochem. Photobiol.
61, 529 (1995),
Abstract;
Photosensitized inhibition of growth factor-regulated protein kinases by hypericin: P. Agostinis, et al.; Biochem. Pharmacol.
49, 1615 (1995),
Abstract;
The chemical and biological properties of hypericin--a compound with a broad spectrum of biological activities: G. Lavie et al.; Med. Res. Rev.
15, 111 (1995),
Abstract;
Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus: D.L. Barnard, et al.; Antiviral Res.
17, 63 (1992),
Abstract;
Photosensitization is required for inactivation of equine infectious anemia virus by hypericin: S. Carpenter & G.a. Kraus ; Photochem. Photobiol.
53, 169 (1991),
Abstract;
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC
165, 1207 (1989),
Abstract;
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin: D. Meruelo, et al.; PNAS
85, 5230 (1988),
Abstract;
