Replaces Prod. #: BML-EI135
Dual inhibitor of 5-lipoxygenase (IC50=8µM) and cyclooxygenase (COX) (IC50=52µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells. Has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10µM), the COP9 signalosome kinase (IC50=10µM) and p300/CBP.
Product Details
Alternative Name: | 1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane |
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Formula: | C21H20O6 |
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MW: | 368.4 |
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Source: | Isolated from turmeric (Curcuma longa). |
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CAS: | 458-37-7 |
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MI: | 14: 2673 |
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Purity: | ≥98% (HPLC) |
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Appearance: | Orange-yellow crystalline powder. |
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Solubility: | Soluble in acetic acid, 100% ethanol (at about 1mg/ml) or DMSO (25mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | Ambient |
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Handling: | Protect from light. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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