| ADI-CSA-600-F | 200 µg | 501.00 USD |  |
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| Clone: | CerCLIP.1 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide corresponding to a portion of human CLIP. |
| UniProt ID: | P04233 |
| GenBank ID: | K01144 |
| Source: | Purified from mouse ascites. |
| Species reactivity: | Human |
| Applications: | Flow Cytometry, IP, WB |
| Recommended Dilutions/Conditions: | Flow Cytometry (1:200) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS containing 0.09% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | CLIP (class II-associated invariant chain peptide) is an important peptide in the MHC-II antigen processing pathway, formed by the enzymatic cleavage of amino acids 81-104 from the invariant chain. During MHC-II synthesis in the ER and transport to endocytic vesicles, the antigen binding site of MHC-II is obstructed by the presence of the invariant chain. As the MHC-II complex moves through the Golgi, the invariant chain is degraded, leaving the CLIP fragment in the MHC-II peptide binding groove. CLIP is eventually displaced by the loading of antigenic peptides, followed by presentation on the APC cell surface to CD4+ T-cells. |
| Regulatory Status: | RUO - Research Use Only |
