| ADI-AAM-227-E | 100 µg | 386.00 USD |  |
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| Alternative Name: | CD95, APO-1, TNFRSF 6 |
| Clone: | ZB4 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human Fas. |
| UniProt ID: | P25445 |
| Species reactivity: | Human |
| Applications: | Flow Cytometry, WB, FUNC |
| Recommended Dilutions/Conditions: | Flow Cytometry (5-20µg/ml) Western Blot (5µg/ml, colorimetric) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~45kDa by Western blot. Functional Application: neutralizing. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, with 50% glycerol. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Fas/APO-1/CD95 is a 36 kDa cell surface type I-membrane glycoprotein that is a member of the Tumor necrosis factor receptor (TNF-R) family, which includes TNF-R1, TNF-R2, CD27, CD30, and CD40. Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis of Fas expressing cells. Apoptosis induced by Fas-Fas ligand interaction is inhibited by a number of cytosolic factors such as the ICE/CED3 family inhibitor CrmA, and the short and long form of FLIP. |
| Regulatory Status: | RUO - Research Use Only |
