| ADI-905-902-0050 | 50 µg | 269.00 USD |  |
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| ADI-905-902-0200 | 200 µg | 539.00 USD | |
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| Do you need bulk/larger quantities? | |||||
| Alternative Name: | Leukotriene C4 |
| Clone: | 6E7 |
| Host: | Mouse |
| Isotype: | IgG |
| Immunogen: | Leukotriene C4 |
| Source: | Purified from mouse ascites. |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | ELISA Radioimmunoassay |
| Recommended Dilutions/Conditions: | Radioimmunoassay (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Leukotrienes are metabolic products of arachidonic acid formed by the action of 5-lipoxygenase (5-LO), with the principal products being leukotrienes C4 (LTC4) and B4 (LTB4). Leukotriene B4 (LTB4) stimulates leukocyte functions including lysosomal enzyme release, adhesion, and aggregation of polymorphonuclear leukocytes. LTB4 has been implicated as a potent mediator of inflammatory diseases and immunoregulation. The cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are formed by addition of cysteine derivatives to LTA4. The conversion of LTA4 to LTC4 by the enzyme LTC4 synthase limits the rate of cysteinyl leukotriene formation. Cysteinyl leukotrienes are potent lipid mediators in inflammation, inducing smooth muscle contractions and increased capillary permeability. |
| Regulatory Status: | RUO - Research Use Only |
