| ADI-905-638-100 | 100 µg | 569.00 USD |  |
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| Alternative Name: | BCL2 antagonist of cell death |
| Clone: | 5E6 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human Bad. |
| UniProt ID: | Q92934 |
| Species reactivity: | Human |
| Applications: | ICC, IHC, IP, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (1:50) Immunoprecipitation (1-2µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~19kDa by Western blot. |
| Purity Detail: | Thiophilic adsorption and size exclusion chromatography purified. |
| Formulation: | Lyophilized from 1ml of 2x PBS containing 0.09% sodium azide, PEG, and sucrose. |
| Reconstitution: | Reconstitute with 1ml water (15 minutes at room temperature). |
| Use/Stability: | Stable at -80°C up to 1 year, at 4°C up to 3 months. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Bad is an ~22 kDa pro-apoptotic protein that aids in the initiation of cell death. It exhibits sequence homology to Bcl-2, a protein that prevents apoptosis, within its BH1 and BH2 domains. Bad is phosphorylated at several sites including Ser112, Ser136; phosphorylation by kinases like Akt is known to alter the effects of Bad. Bad has been demonstrated to be phosphorylated at Ser170. |
| Regulatory Status: | RUO - Research Use Only |
