| Alternative Name: | LF, ALF |
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| Clone: | LF2 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Anthrax lethal factor. |
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| UniProt ID: | P15917 |
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| Source: | Purified from hybridoma tissue culture supernatant. |
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| Species reactivity: | Bacillus anthracis
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| Applications: | ELISA, IP, WB
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.01% sodium azide. Concentration 1mg/ml. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Anthrax Lethal Factor (LF) is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinase (MAPKK) and causes lysis of macrophages. LF, together with Protective Antigen, forms Lethal Toxin, which is the dominant virulence factor produced by B. anthracis and is the major cause of death in infected animals. Lethal toxin has been reported to trigger apoptosis in human melanoma cells. |
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| Regulatory Status: | RUO - Research Use Only |
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