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Nampt (Visfatin/PBEF)

Nicotinamide phosphoribosyltransferase (Nampt) is the rate limiting enzyme in the conversion of nicotinamide to nicotinamide adenine dinucleotide (NAD), a classic coenzyme of cellular redox reactions. Nampt was originally identifi ed as a presumptive cytokine for B cell maturation and named Pre-B cell colony enhancing factor (PBEF). Recently, Nampt was discovered to be a visceral fat-derived adipokine and also named Visfatin. Fukuhara et al. showed that Nampt (Visfatin/PBEF) exerts insulin-mimetic effects in animal models, stimulates glucose uptake into muscle cells and adipocytes, suppresses glucose release from hepatocyte, and binds the insulin receptor. These observations draw much attention but subsequent studies reported confl icting results regarding its relation with adiposity, with subcutaneous or visceral fat and with insulin resistance. Others could not repeat the insulin-mimetic effects and the Fukuhara work was subsequently retracted. Interestingly, while the insulin-mimetic effect is unclear secreted Nampt (Visfatin/PBEF) has recently been shown to regulate insulin secretion in β cells. Nampt (Visfatin/PBEF) has also been shown to be a cell survival factor and to be involved in subclinical infl ammation.
 

Control of Insulin Secretion by Nampt (Visfatin/PBEF). Nampt (Visfatin/PBEF) secreted from adipose tissue converts nicotinamide to NMN, which crosses the
 

Nampt (Visfatin/PBEF) Proteins

eNampt (Visfatin/PBEF) (human), (recombinant) 

Produced in CHO cells. Secreted from the cells using a proprietary signal peptide. Full length extracellular human Nampt (visfatin/PBEF) (aa 1-491) is fused at the N-terminus to a FLAG®-tag., ≥95% (SDS-PAGE) | Print as PDF
 
ALX-201-336-C010 10 µg Inquire for pricing
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Nampt (Visfatin/PBEF) (rat), (recombinant) (His-tag) 

Produced in E. coli. Full length rat Nampt (visfatin/PBEF) (aa 1-491) is fused at the C-terminus to a His-tag., ≥90% (SDS-PAGE) | Print as PDF
 
ALX-201-332-C050 50 µg 519.00 USD
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Nampt (Visfatin/PBEF) Antibodies

Nampt (Visfatin/PBEF) (human) polyclonal antibody 

ELISA, WB | Print as PDF
 
ALX-210-425-C100 100 µg 320.00 USD
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Nampt (Visfatin/PBEF) (human) (NT) polyclonal antibody 

ELISA, WB | Print as PDF
 
ALX-210-426-C100 100 µg 330.00 USD
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