Potent agonist (EC50=50nM) of the orphan nuclear hormone receptor (liver X receptor; LXR). Inhibitor of human sex hormone-dependent cancer cell lines.
Product Details
| Alternative Name: | N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide |
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| Formula: | C17H12NF9O3S |
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| MW: | 481.3 |
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| CAS: | 293754-55-9 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by MS. |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | 50mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or any organic solvent; also soluble in a 1:1 solution of DMSO:PBS, pH 7.2 (500µg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | We do not recommend storing the aqueous solutions for more than one day. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Validation and application of a novel cholesterol efflux assay using immobilized liposomes as a substitute for cultured cells: Y. Horiuchi, et al.; Biosci. Rep.
38, BSR20180144 (2018),
Abstract;
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AMPK activates LXRα and ABCA1 expression in human macrophages: M. Kemmerer, et al.; Int. J. Biochem. Cell Biol.
16, 30154 (2016),
Application(s): Cell culture using human monocytic cells,
Abstract;
The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells: C.P. Chuu et al.; Biochem. Biophys. Res. Commun.
357, 341 (2007),
Abstract;
Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells: J. Fukuchi, et al.; Cancer Res.
64, 7686 (2004),
Abstract;
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands: R.A. DeBose-Boyd, et al.; PNAS
98, 1477 (2001),
Abstract;
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LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes: B.A. Laffitte, et al.; PNAS
98, 507 (2001),
Abstract;
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Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers: J.J. Repa, et al.; Science
289, 1524 (2000),
Abstract;
Role of LXRs in control of lipogenesis: J.R. Schultz, et al.; Genes Dev.
14, 2831 (2000),
Abstract;
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