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United States 

Momelotinib

Selective inhibitor of JAK1 and JAK2 kinases including the JAK2 V617F mutant
 
ENZ-CHM197-0001 1 mg 55.00 USD
 
ENZ-CHM197-0005 5 mg 105.00 USD
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Using ATP kinase assays, the IC50 values for CYT387 are a follows - JAK1 (11nM), JAK2, (18nM), JAK2 V617F (23nM) JAK3 (155nM), and TYK2 (17nM). In testing kinase arrays, CYT387 also had activity (defined as an IC50 < 100nM) detected against CDK2/cyclin A, MAPK8 (JNK1), PRKCN (PKD3), PRKD1 (PKCμ), ROCK2, and TBK1 kinase as well.

Product Specification

Alternative Name:CYT 387, N-​​(cyanomethyl)​-​​4-​​[2-​​[[4-​​(4-​​morpholinyl)​phenyl]​amino]​-​​4-​​pyrimidinyl]​-​benzamide
 
Formula:C23H22N6O2
 
MW:414.5
 
CAS:1056634-68-4
 
Purity:≥97% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Yellow to orange powder.
 
Solubility:Soluble in DMSO (>20mM).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
ENZ-CHM197 structure
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ENZ-CHM197 structure

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