Potent and selective AMPK inhibitor. Dorsomorphin also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK-2), BMPR-IA (ALK-3), and BMPR-IB (ALK-6).
Product Details
| Alternative Name: | 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride |
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| Formula: | C24H25N5O . 2 HCl |
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| MW: | 472.4 |
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| CAS: | 1219168-18-9 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | Light yellow powder solid. |
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| Solubility: | Soluble in DMSO or water. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -80°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A temporal Ca 2+-desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKß/PP2A pathways: T. Kitazawa, et al.; Am. J. Physiol. Cell Physiol.
321, C549 (2021),
Abstract;
A rare human CEP290 variant disrupts the molecular integrity of the primary cilium and impairs Sonic Hedgehog machinery: M.B.C. Kilander, et al.; Sci. Rep.
8, 17355 (2018),
Abstract;
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