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Irisin (human) polyclonal antibody

ENZ-ABS256-0100 100 µg 379.00 USD
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Product Details

Alternative Name:FNDC5, Fibronectin type III domain-containing protein 5, FRCP2, Fibronectin type III repeat-containing protein 3
Immunogen:Recombinant human Irisin (active).
UniProt ID:Q8NAU1
Source:Purified from rabbit serum.
Species reactivity:Human
Applications:ELISA, IP, WB
Positive Control:ADI-908-307
Purity Detail:Protein A affinity purified and immunodepleted.
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Short Term Storage:-20°C
Long Term Storage:-20°C
Scientific Background:Irisin is a hormone that is involved in converting white adipose tissue into brown adipose tissue after physical exercise. It is formed after the membrane bound protein fibronectin type III domain containing protein 5 (FNDC5) is cleaved resulting in a secreted protein. FNDC5 is found in muscle tissue and is activated during physical exertion via the protein PGC1a. Soluble Irisin has also been shown to up regulate UCP-1 gene expression in mice. UCP-1 is a mitochondrial transporter protein and a marker of brown adipose tissue conversion. This suggests that Irisin plays an important role in energy regulation and furthermore may lead to improvements in glucose regulation, insulin sensitivity, hypertension, and obesity.
Regulatory Status:RUO - Research Use Only

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Produced in CHO cells. aa 32-143, also known as Irisin, comprises the majority of the extracellular domain of FNDC5. It is fused at the N-terminus to a FLAG®-tag with an 8 aa linker between the FLAG®-tag and Irisin., ≥90% (SDS-PAGE), ELISA, WB, Activity assay, SDS-PAGE | Print as PDF
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