MQAE is a fluorescent chloride ion indicator that is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells. MQAE is a fluorescent indicator that is quenched via collision with chloride. The probe is suitable for detection of chloride concentrations in liposomes, reconstituted membranes or in extracellular medium. As a UV-excitable indicator, MEQ can be detected using an argon-ion laser for confocal microscopy and flow cytometry applications. MQAE has greater sensitivity than SPQ and higher fluorescence quantum yield. The ester group of MQAE may slowly hydrolyze inside cells, resulting in a change in its fluorescence response. Wavelength Maxima: Excitation 350nm, Emission 460nm
Product Details
| Alternative Name: | N-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide |
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| Formula: | C14H16BrNO3 |
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| MW: | 326.2 |
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| CAS: | 162558-52-3 |
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| Purity: | ≥98% (HPLC) |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least one year after receipt when stored as recommended. |
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| Handling: | Protect from light. Keep cool and dry. |
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| Technical Info/Product Notes: | This product is a member of the CELLESTIAL® product line, reagents and assay kits comprising fluorescent molecular probes that have been extensively benchmarked for live cell analysis applications. CELLESTIAL® reagents and kits are optimal for use in demanding imaging applications, such as confocal microscopy, flow cytometry and HCS, where consistency and reproducibility are required. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Measurement of halide efflux from cultured and primary airway epithelial cells using fluorescence indicators: F. Munkonge, et al.; J. Cyst. Fibros.
3 Suppl. 2, 171 (2004),
Abstract;
Modulation of intracellular Cl- homeostasis by lectin-stimulation in Jurkat T lymphocytes: Z.F. Lai, et al.; Eur. J. Pharmacol.
482, 1 (2003),
Abstract;
