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IκBα (human), (recombinant) (untagged)

BML-UW9975-0050 50 µg 287.00 USD
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Product Details

Source:Produced in E. coli.
UniProt ID:P25963
Formulation:Liquid. In 50mM HEPES, pH 7.5, containing 200mM sodium chloride and 1mM DTT.
Application Notes:Uses:
1. NF-κB pathway studies, inhibition of NF-κB p50/p65, substrate for IκB kinase (IKK).
2.Investigation of IκBα phosphorylation/ubiquitinylation/SUMOylation.
3. Ubiquitin-proteasome mediated degradation studies.
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:IκBa inhibits activation of the NF-κB pathway activation by associating with the major NF-κB heterodimeric complex p50/p65 and preventing its translocation from the cytoplasm into the nucleus, where it acts a transcription factor for genes involved in inflammation, autoimmune response, cell proliferation, and apoptosis. Inhibition of NF-κB pathway activation by IκBα is controlled by its sequential serine-phosphorylation, ubiquitination and proteasomal degradation. This process itself can be inhibited by SUMOylation of IκBα, providing an additional regulatory step for the activation of the NF-κB pathway.
Regulatory Status:RUO - Research Use Only
IkappaBalpha (human), (recombinant) (untagged) SDS-PAGE
SDS-PAGE analysis of Prod. No. BML-UW9975: Lane 1: MW marker, Lane 2: 1µg IκBα (human), (recombinant) (untagged).
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IkappaBalpha (human), (recombinant) (untagged) SDS-PAGE

Product Literature References

An electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation: Y.S. Kim, et al.; Chem. Biol. 20, 604 (2013), Abstract; Full Text

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