Replaces Prod. #: ALX-350-288
Mycalolide B is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM). It selectively and completely depolymerizes F-actin to G-actin via a mechanism distinct from that of the cytochalasins. Unlike cytochalasins, it inhibits actin-activated Mg2+-ATPase from rabbit skeletal muscle.
Product Details
| Formula: | C52H74N4O17 |
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| MW: | 1027.2 |
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| Source: | Isolated from the marine sponge Mycale sp. |
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| CAS: | 122752-21-0 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Clear to white solid |
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| Solubility: | Soluble in DMSO, methanol or isopropanol |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Toxoplasma gondii-Induced Neutrophil Extracellular Traps Amplify the Innate and Adaptive Response: F.J.B. Miranda, et al.; Mbio
12, e0130721 (2021),
Abstract;
TgTKL1 Is a Unique Plant-Like Nuclear Kinase That Plays an Essential Role in Acute Toxoplasmosis: J.M. Varberg, et al.; Mbio.
9, e00301-18 (2018),
Abstract;
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Nuclear herpesvirus capsid motility is not dependent on F-actin: J.B. Bosse, et al.; MBio
5, e01909 (2014),
Abstract;
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Actin filaments play an essential role for transport of nascent HIV-1 proteins in host cells: H. Sasaki et al.; Biochem. Biophys. Res. Commun.
316, 588 (2004),
Abstract;
Uncoupling of gate and fence functions of MDCK cells by the actin-depolymerizing reagent mycalolide B: R. Takakuwa; Exp. Cell. Res.
257, 238 (2000),
Abstract;
Actin-binding specificity of marine macrolide toxins, mycalolide B and kabiramide D: S. Wada et al.; J. Biochem.
123, 946 (1998),
Abstract;
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem.
123, 571 (1998),
Abstract;
Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D: A. Sugidachi et al.; Thromb. Haemost.
79, 614 (1998),
Abstract;
A family of novel actin-inhibiting marine toxins: S. Saito & H. Karaki ; Clin. Exp. Pharmacol. Physiol.
23, 743 (1996),
Abstract;
Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge: S. Watabe et al.; Cell. Struct. Funct.
21, 199 (1996),
Abstract;
Mycalolide B, a novel actin depolymerizing agent: S.Saito et al.; J. Biol. Chem.
269, 29710 (1994),
Abstract;
Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge: M. Hori et al.; FEBS Lett.
322, 151 (1993),
Abstract;
General Literature References
Makrolide aus marinen Organismen: G. Schilling; Labor&more 1.12, 32 (2012),
